Irradiance-dependent UVB Photocarcinogenesis

Published on Dec 1, 2016in Scientific Reports4.011
· DOI :10.1038/srep37403
Cheng-Che E. Lan21
Estimated H-index: 21
Ching-Shuang Wu13
Estimated H-index: 13
+ 6 AuthorsGwo-Shing Chen25
Estimated H-index: 25
Ultraviolet B (UVB) radiation from the sun may lead to photocarcinogenesis of the skin. Sunscreens were used to protect the skin by reducing UVB irradiance, but sunscreen use did not reduce sunburn episodes. It was shown that UVB-induced erythema depends on surface exposure but not irradiance of UVB. We previously showed that irradiance plays a critical role in UVB-induced cell differentiation. This study investigated the impact of irradiance on UVB-induced photocarcinogenesis. For hairless mice receiving equivalent exposure of UVB radiation, the low irradiance (LI) UVB treated mice showed more rapid tumor development, larger tumor burden, and more keratinocytes harboring mutant p53 in the epidermis as compared to their high irradiance (HI) UVB treated counterpart. Mechanistically, using cell models, we demonstrated that LI UVB radiation allowed more keratinocytes harboring DNA damages to enter cell cycle via ERK-related signaling as compared to its HI UVB counterpart. These results indicated that at equivalent exposure, UVB radiation at LI has higher photocarcinogenic potential as compared to its HI counterpart. Since erythema is the observed sunburn at moderate doses and use of sunscreen was not found to associate with reduced sunburn episodes, the biological significance of sunburn with or without sunscreen use warrants further investigation.
  • References (37)
  • Citations (10)
📖 Papers frequently viewed together
26 Citations
47 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Machiko Iida (Nagoya University)H-Index: 7
#2Chihiro Nakano (Nagoya University)H-Index: 3
Last. Masashi Kato (Nagoya University)H-Index: 43
view all 6 authors...
7 CitationsSource
#1Howard W. Rogers (Norwich University)H-Index: 5
#2Martin A. WeinstockH-Index: 64
Last. Brett M. Coldiron (UC: University of Cincinnati)H-Index: 26
view all 4 authors...
Importance Understanding skin cancer incidence is critical for planning prevention and treatment strategies and allocating medical resources. However, owing to lack of national reporting and previously nonspecific diagnosis classification, accurate measurement of the US incidence of nonmelanoma skin cancer (NMSC) has been difficult. Objective To estimate the incidence of NMSC (keratinocyte carcinomas) in the US population in 2012 and the incidence of basal cell carcinoma (BCC) and squamous cell ...
373 CitationsSource
#1Reza Ghiasvand (University of Oslo)H-Index: 18
#2Eiliv Lund (University of Tromsø)H-Index: 95
Last. Marit B. Veierød (University of Oslo)H-Index: 42
view all 5 authors...
Summary Background Sunscreen is recommended to prevent sunburn and skin cancer. Objectives To investigate sunscreen use in relation to demographic and phenotypic characteristics among women in Norway, as well as solar UV exposure, sunburn experience in different decades of life, and temporal trends in sunscreen use. Methods We used data from the Norwegian Women and Cancer Study, a large population-based prospective cohort study. Log-binomial regression was used to estimate the association betwee...
22 CitationsSource
#1Stephen Chu-Sung Hu (KMU: Kaohsiung Medical University)H-Index: 11
#2Hsin-Su Yu (KMU: Kaohsiung Medical University)H-Index: 32
Last. Cheng-Che E. Lan (KMU: Kaohsiung Medical University)H-Index: 21
view all 5 authors...
The chemokine receptor CXCR7 has been demonstrated to be involved in the development of certain cancers, but its role in cutaneous squamous cell carcinoma (SCC) has not been previously investigated. We seek to determine whether CXCR7 is expressed in human cutaneous SCC skin lesions and SCC cell lines. In addition, we evaluate whether CXCR7 plays a role in SCC cell proliferation, survival and migration and which signalling pathways are involved. Using quantitative RT-PCR to analyse the mRNA expre...
9 CitationsSource
Non-melanoma skin cancer (NMSC) is the most common malignancy, whose public health significance is often unrecognized. This analysis has two objectives: first, to provide up-to-date incidence estimates by sex, age group, histological type, and body site; and second, to study the impact of skin cancer screening. The impact of screening on NMSC incidence in Schleswig-Holstein, Germany, is analyzed by comparing four time periods of different screening settings (no screening (1998–2000), pilot proje...
123 CitationsSource
#1Fatemeh NavidH-Index: 7
#2Anika BruhsH-Index: 6
Last. Agatha SchwarzH-Index: 40
view all 7 authors...
UVR suppresses the immune system through the induction of regulatory T cells (Tregs). UVR-induced DNA damage has been recognized as the major molecular trigger involved, as reduction of DNA damage by enhanced repair prevents the compromise to the immune system by UVR. Nevertheless, other signaling events may also be involved. The aryl hydrocarbon receptor (AhR) was identified as another target for UVR, as UVR activates the AhR and certain UVR effects were not detected in AhR-deficient cells. We ...
23 CitationsSource
#1B. Petersen (UCPH: University of Copenhagen)H-Index: 10
#2Elisabeth Thieden (UCPH: University of Copenhagen)H-Index: 19
Last. Antony R Young ('KCL': King's College London)H-Index: 1
view all 6 authors...
Summary Background A great number of journeys to sunny destinations are sold to the Danish population every year. We suspect that this travel considerably increases personal annual ultraviolet-radiation (UVR) exposure doses. This is important because such exposure is the main cause of skin cancer, and studies have shown a correlation between intermittent solar UVR exposure and malignant melanoma. Objectives To prospectively monitor the behaviour of a group of sun seekers during a winter sun holi...
21 CitationsSource
#1Cheng-Che E. Lan (KMU: Kaohsiung Medical University)H-Index: 21
#2Hsin-Su Yu (KMU: Kaohsiung Medical University)H-Index: 32
Last. Hsiao-Chi Lai (KMU: Kaohsiung Medical University)H-Index: 2
view all 5 authors...
Summary Light exposure modulates development of living organisms. In the field of medicine, light has frequently been used for regenerative purposes. Excimer light (308 nm) has demonstrated superior efficacy in treating vitiligo, a condition requiring development of melanoblasts and a model for studying nerve cell regeneration, as compared to narrow-band ultraviolet B (NBUVB; 311 nm). Using mouse-derived melanoblast cells to examine the pro-differentiation effects of these two light sources, we ...
14 CitationsSource
#1Keitaro Yamane (Kumamoto University)H-Index: 12
#2Masatoshi Jinnin (Kumamoto University)H-Index: 37
Last. Hironobu Ihn (Kumamoto University)H-Index: 51
view all 13 authors...
Squamous cell carcinoma (SCC) is one of the most common skin cancers. Because its potential to recur and metastasize leads to a poor prognosis and significant mortality, it is necessary to develop new early diagnostic tools and new therapeutic approaches. In this study, we found protein levels of ERK1 and ERK2 were increased in SCC cell lines without changing mRNA levels and that ERK1/2 mediates abnormal cell proliferation in these cells. Then, mechanisms underlying the overexpression of ERK1/2 ...
51 CitationsSource
#1A. LomasH-Index: 1
#2Jo Leonardi-BeeH-Index: 44
Last. Fiona Bath-Hextall (University of Nottingham)H-Index: 24
view all 3 authors...
Summary Background Nonmelanoma skin cancer (NMSC) is the most common cancer affecting white-skinned individuals and the incidence is increasing worldwide. Objectives This systematic review brings together 75 studies conducted over the past half century to look at geographical variations and trends worldwide in NMSC, and specifically incidence data are compared with recent U.K. cancer registry data. Methods Following the development of a comprehensive search strategy, an assessment tool was adapt...
722 CitationsSource
Cited By10
#1Hui-Ju Yang (CSMU: Chung Shan Medical University)H-Index: 1
Last. Jiunn‐Liang Ko (CSMU: Chung Shan Medical University)
view all 5 authors...
BACKGROUND: Vitiligo is an acquired disease that involves low pigment variation in the skin. The use of cultured melanocytes for treatment of recalcitrant vitiligo has become a well-established treatment modality. In vitro cultured melanocytes present an effective autologous transplantation treatment modality for vitiligo. The present study investigated the in vitro culture of epidermal melanocytes sampled from multiple body parts, as well as the differences in total propagation time. METHODS: S...
#1Ting-Ting Yang (KMU: Kaohsiung Medical University)
#2Szu-Hao Chiu (KMU: Kaohsiung Medical University)
Last. Cheng‐Che E. Lan (KMU: Kaohsiung Medical University)
view all 3 authors...
Phototherapy is the most commonly used modality for repigmenting vitiligo. Currently, UVB emitting devices, including narrow-band UVB (NBUVB) and excimer laser/light, are considered as the treatment of choice. While emitting wavelengths at close proximity, excimer lights emit higher irradiance (HI; W/m(2) ) compared to NBUVB. Clinical reports have shown that excimer light is more efficacious in treating vitiligo compared to NBUVB, and we demonstrated that irradiance plays a critical role in prom...
#1Yu Wen Huang (ISU: I-Shou University)
#2Han Hsiang Huang (NCYU: National Chiayi University)H-Index: 5
Last. Shyh Ming Kuo (ISU: I-Shou University)H-Index: 16
view all 6 authors...
BACKGROUND: Farnesol is an acyclic sesquiterpene presents in various natural sources including fruits, vegetables, and herbs. In this study, we successfully prepared a farnesol-containing gel with ultraviolet B-screening and skin-repairing capabilities. Furthermore, the advantageous potential of farnesol-containing facial masks for UVB-caused sunburnt skin was evaluated. AIMS: Thus, the objectives of this study are to design and prepare optimal facial masks possessing collagen production and smo...
1 CitationsSource
#1Hui Hua (PRC: China Medical University (PRC))
#2Tianyao Yang (PRC: China Medical University (PRC))
Last. Yang Liu (PRC: China Medical University (PRC))H-Index: 22
view all 9 authors...
UV-B radiation may be an important risk factor in cataracts aetiology. After exposure to UV-B radiation, cells show imbalances in the repair of DNA damage, which induce changes in the levels of certain proteins, including alpha-crystallin, which is the most abundant protein in the lens and crucial for the maintenance of lens transparency. Lanosterol synthase (LSS), an essential rate-limiting enzyme in cholesterol biosynthesis, might play significant roles in oxidative stress and in the maintenan...
#1Cheng-Che E. Lan (KMU: Kaohsiung Medical University)H-Index: 21
#2Yu-Ting Hung (KMU: Kaohsiung Medical University)H-Index: 1
Last. Wu Ching-Shuang (NSYSU: National Sun Yat-sen University)H-Index: 1
view all 4 authors...
Abstract Background Ultraviolet A (UVA) radiation is the most relevant component of solar radiation-induced skin aging. Sunscreens were used to minimize the harmful effects of UV radiation on our skin by reducing UV irradiance. We previously found that at equivalent fluence, UVB radiation at low irradiance (LI) has higher photocarcinogenic potential as compared to its high irradiance (HI) counterpart. Objectives To examine the effects of equivalent fluence of UVA radiation administered at differ...
1 CitationsSource
#1Hsiao-Chi Lai (KMU: Kaohsiung Medical University)H-Index: 2
#2Chang-Shen Lin (KMU: Kaohsiung Medical University)
Last. Cheng-Che E. Lan (KMU: Kaohsiung Medical University)H-Index: 21
view all 4 authors...
Abstract Background Ultraviolet B (UVB) is commonly used for treating dermatologic conditions. Recently, high irradiance UVB (HIUVB) has been suggested to be more effective for treating skin conditions as compared to its low irradiance (LI) counterpart. The biological impact of UVB radiation emitted at different irradiance on cutaneous immunity remains obscure. Objective This study aimed to explore the impacts of UVB radiation administered at equivalent fluence (mJ/cm2) but different irradiance ...
#1Cheng-Che E. Lan (KMU: Kaohsiung Medical University)H-Index: 21
: Solar radiation is one of fundamental elements sustaining and maintaining life on earth. Previous studies on health effects from the sun exposure mostly focused on ultraviolet (UV) radiation. Although exposure to the solar radiation likely occurs in an environment with elevated temperature, the effects and interactions of elevated environmental temperature with UV radiation on the skin, especially in the context of ageing and carcinogenesis, have not been carefully examined. It is known that U...
1 CitationsSource
#1Blake Ferguson (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
#2Herlina Y. Handoko (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 13
Last. Graeme J. Walker (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 25
view all 7 authors...
Melanoma is a type of skin cancer. Melanoma tumors form in the skin’s pigment-producing cells or melanocytes. Growing evidence points to complex interactions between genetics and environmental exposures that contribute to the risk of developing melanoma. Ultraviolet (UV) radiation from the sun causes genetic mutations in melanocytes. This sun exposure interacts with genetic variations that may make people more or less vulnerable to such DNA damage. For example, genetic variations that control sk...
1 CitationsSource
#1Graeme J. Walker (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 25
#2Blake Ferguson (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
Last. Grant MorahanH-Index: 45
view all 7 authors...
Genetic variation conferring resistance and susceptibility to carcinogen-induced tumorigenesis is frequently studied in mice. We have now turned this to melanoma using the collaborative cross (CC), a resource of mouse strains designed to discover genes for complex diseases. We studied melanoma-prone transgenic progeny across seventy CC genetic backgrounds. We mapped a strong quantitative trait locus for rapid onset spontaneous melanoma onset to Prkdc , a gene involved in detection and repair of ...
#1Martha Paola Mireles-Canales (Autonomous University of Chihuahua)H-Index: 1
#2Susana Aideé González-Chávez (Autonomous University of Chihuahua)H-Index: 6
Last. César Pacheco-Tena (Autonomous University of Chihuahua)H-Index: 21
view all 5 authors...
Systemic lupus erythematosus (SLE) is a perplexing and potentially severe disease, the pathogenesis of which is yet to be understood. SLE is considered to be a multifactorial disease, in which genetic factors, immune dysregulation, and environmental factors, such as ultraviolet radiation, are involved. Recently, the description of novel genes conferring susceptibility to develop SLE even in their own (monogenic lupus) has raised the interest in DNA dynamics since many of these genes are linked t...
1 CitationsSource