Robust, universal biomarker assay to detect senescent cells in biological specimens
Abstract
Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. Here, we designed and synthesized a lipophilic, biotin-linked Sudan Black B (SBB) analogue suitable for sensitive and specific, antibody-enhanced detection of lipofuscin-containing senescent cells in any biological material. This new hybrid histo-/immunochemical method is easy to...
Paper Details
Title
Robust, universal biomarker assay to detect senescent cells in biological specimens
Published Date
Feb 1, 2017
Journal
Volume
16
Issue
1
Pages
192 - 197
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History