Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry
Abstract
Nuclear entry is a selective, dynamic process granting the HIV-1 pre-integration complex (PIC) access to the chromatin. Classical analysis of nuclear entry of heterogeneous viral particles only yields averaged information. We now have employed single-virus fluorescence methods to follow the fate of single viral pre-integration complexes (PICs) during infection by visualizing HIV-1 integrase (IN). Nuclear entry is associated with a reduction in...
Paper Details
Title
Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry
Published Date
Nov 10, 2016
Journal
Volume
6
Issue
1
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