Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage
Abstract
A variety of endogenous and exogenous agents can induce DNA damage and lead to genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging agents, are constantly generated in cells as a consequence of endogenous metabolism, infection/inflammation, and/or exposure to environmental toxicants. A wide array of DNA lesions can be induced by ROS directly, including single-nucleobase lesions, tandem lesions, and hypochlorous...
Paper Details
Title
Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage
Published Date
Nov 7, 2016
Volume
29
Issue
12
Pages
2008 - 2039
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