Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages

Volume: 198, Issue: 1, Pages: 492 - 504
Published: Nov 23, 2016
Abstract
Alveolar macrophages (AMϕ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMϕ self-renewal remain poorly understood. We found that myeloid-specific deletion of Raptor, an essential component of the mammalian/mechanistic target of rapamycin complex (mTORC)1, resulted in a marked decrease of this population of cells accompanying altered phenotypic features and impaired phagocytosis activity. We...
Paper Details
Title
Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages
Published Date
Nov 23, 2016
Volume
198
Issue
1
Pages
492 - 504
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.