Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages
Abstract
Alveolar macrophages (AMϕ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMϕ self-renewal remain poorly understood. We found that myeloid-specific deletion of Raptor, an essential component of the mammalian/mechanistic target of rapamycin complex (mTORC)1, resulted in a marked decrease of this population of cells accompanying altered phenotypic features and impaired phagocytosis activity. We...
Paper Details
Title
Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages
Published Date
Nov 23, 2016
Journal
Volume
198
Issue
1
Pages
492 - 504
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