Match!

Sudden cardiac death in transposition of the great arteries with a Mustard or Senning baffle: the myocardial ischemia hypothesis.

Published on Jan 1, 2017in Current Opinion in Cardiology1.979
· DOI :10.1097/HCO.0000000000000353
Paul Khairy38
Estimated H-index: 38
Abstract
Purpose of reviewThe literature on sudden death in transposition of the great arteries (D-TGA) with atrial switch surgery is reviewed and a pathophysiological mechanism is proposed.Recent findingsOver 80% of sudden deaths in patients with D-TGA and Mustard or Senning baffles occur during exercise. F
  • References (25)
  • Citations (14)
📖 Papers frequently viewed together
150 Citations
69 Citations
242 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References25
Newest
Remarkable gains in survival have led to an unprecedented number of adults with congenital heart disease. Arrhythmias collectively comprise the most common complication encountered. Recognising the unique issues and challenges involved in managing arrhythmias in adults with congenital heart disease and the consequential decisions surrounding sudden death prevention, expert societies have proposed evidence-based recommendations. On the whole, acute ventricular arrhythmias are managed according to...
25 CitationsSource
#1Jim T. VehmeijerH-Index: 5
#2Tom F. BrouwerH-Index: 13
Last. Joris R. de GrootH-Index: 31
view all 7 authors...
Aims Sudden cardiac death is a major cause of mortality in adult congenital heart disease (ACHD) patients. The indications for implantable cardioverter-defibrillator (ICD) implantation in ACHD patients are still not well established. We aim to systematically review the literature on indications and outcome of ICD implantation in ACHD patients. Methods and results We performed a comprehensive search in EMBASE, MEDLINE, and Google Scholar to identify all studies on ICD implantation in ACHD patient...
40 CitationsSource
#1Marie-A. Chaix (MHI: Montreal Heart Institute)H-Index: 4
#2François Marcotte (MHI: Montreal Heart Institute)H-Index: 16
Last. Paul Khairy (MHI: Montreal Heart Institute)H-Index: 45
view all 7 authors...
Exercise capacity in adults with various forms of congenital heart disease is substantially lower than that of the general population. Although the underlying congenital heart defect, and its sequelae, certainly contribute to observed exercise limitations, there is evidence suggesting that deconditioning and a sedentary lifestyle are important implicated factors. The prevalence of acquired cardiovascular comorbidities is on the increase in the aging population with congenital heart disease, such...
28 CitationsSource
#1Paul Khairy (UdeM: Université de Montréal)H-Index: 45
#2Van Hare GfH-Index: 48
Last. Carole A. Warnes (UdeM: Université de Montréal)H-Index: 56
view all 22 authors...
188 CitationsSource
#1Miriam Wheeler (Royal Melbourne Hospital)H-Index: 4
#2Leeanne E. Grigg (Royal Melbourne Hospital)H-Index: 34
Last. D. Zentner Fracp (Royal Melbourne Hospital)H-Index: 8
view all 3 authors...
17 CitationsSource
#1Fracp Miriam Wheeler MBChB (Royal Melbourne Hospital)H-Index: 1
#2Fracp and Leeanne Grigg Mbbs (Royal Melbourne Hospital)H-Index: 1
Last. Fracp Dominica Zentner Mbbs (Hons) (Royal Melbourne Hospital)H-Index: 1
view all 3 authors...
Objective This study aims to identify predictors of sudden cardiac death (SCD) in patients with transposition of the great arteries (TGA) who have undergone atrial baffle surgery with the Mustard or Senning operation. Background Patients with TGA and previous atrial baffle surgery are known to be at increased risk of SCD. Despite this, indications for insertion of an implantable cardiac defibrillator for primary prevention have not been established. Methods Eighty-nine patients with a diagnosis ...
13 CitationsSource
#1Zeliha KoyakH-Index: 10
#2Louise Harris (U of T: University of Toronto)H-Index: 37
Last. Barbara J.M. MulderH-Index: 62
view all 10 authors...
Background—Sudden cardiac death (SCD) is a major cause of mortality in adults with congenital heart disease (CHD). The aim of this study was to determine the adult CHD population at risk of SCD and the clinical parameters associated with SCD. Methods and Results—We performed a multicenter case-control study. Patients who died suddenly as a result of proven or presumed arrhythmia were included (cases). For each case, 2 controls matched on diagnosis, type of surgical intervention, age, and gender ...
177 CitationsSource
#1A. Carla Zomer (UU: Utrecht University)H-Index: 10
#2Ilonca Vaartjes (UU: Utrecht University)H-Index: 22
Last. Barbara J.M. MulderH-Index: 62
view all 12 authors...
Abstract Background Circumstances of death have been described for various cardiovascular diseases, but this study is the first for adults with congenital heart disease (CHD). Methods Review of medical records and additional information from treating cardiologists and general practitioners, for circumstances of all deaths in a national registry of over 8000 adults with CHD. Results Of 8595 patients, 231 (2.7%) patients died over 26,500 patient years. Main causes of death were progressive heart f...
75 CitationsSource
#1Markus Schwerzmann (University of Bern)H-Index: 30
#2Omid Salehian (McMaster University)H-Index: 21
Last. Candice K. Silversides (UHN: University Health Network)H-Index: 45
view all 9 authors...
Aims To examine the prevalence of sustained ventricular tachycardia (VT) and sudden death (SD) in adults with atrial repair of transposition of the great arteries (TGA) and to determine associated risk factors. Methods and results In a single-centre review, we studied the outcome of 149 adults (mean age 28 ± 7 years) who had undergone a Mustard operation for TGA. During a mean follow-up of 9 ± 6 years, sustained VT and/or SD occurred in 9% (13/149) of the cohort. Sustained VT/SD was more likely ...
124 CitationsSource
Background —Transposition of the great arteries (D-TGA) with intra-atrial baffle repair is among the congenital heart defects at highest risk of sudden death. Little is known about mechanisms of sudden death and the role of implantable cardioverter-defibrillators (ICDs). Methods and Results —We conducted a multicenter cohort study in patients with D-TGA to determine actuarial rates of ICD shocks, identify risk factors, assess underlying arrhythmias, and characterize complications. Overall, 37 pa...
150 CitationsSource
Cited By14
Newest
Abstract Background To assess the relationship between heart rate response and exercise tolerance in adults with systemic right ventricle (sRV) after atrial switch repair for Transposition of the Great Artery (TGA) in addition to other physiological parameters. Methods All patients with a sRV after atrial switch repair for TGA followed in our institution between June 2015 and April 2018 who underwent cardiopulmonary exercise testing (CPET) were analyzed. Cardiac imaging performed within a six-mo...
Source
#1Lorenzo Gitto (State University of New York Upstate Medical University)
#2Serenella Serinelli (State University of New York Upstate Medical University)
Last. Steven WhiteH-Index: 1
view all 4 authors...
Source
#1Lauren Andrade (UPenn: University of Pennsylvania)
#2Matthew Carazo (Emory University)H-Index: 1
Last. William Wilson (University of Melbourne)
view all 5 authors...
There are two predominant scenarios where the right ventricle acts as the systemic ventricle, namely congenitally corrected transposition of the great arteries (CC-TGA) and patients with D-transposition of the great arteries (D-TGA) who have undergone an atrial switch operation. There is evidence that having a right ventricle in the systemic position predisposes to the development of heart failure. In this review, we aim to explore the proposed mechanisms and pathophysiology for heart failure in...
Source
#1Marie-A. Chaix (MHI: Montreal Heart Institute)H-Index: 4
#2May Chergui (UdeM: Université de Montréal)H-Index: 1
Last. Paul Khairy (MHI: Montreal Heart Institute)H-Index: 45
view all 4 authors...
Abstract Background Sudden death is the leading cause of mortality in patients with transposition of the great arteries (TGA) and atrial switch surgery. Understanding underlying mechanisms could contribute to identifying high-risk patients and preventing such catastrophic deaths. Methods A total of 144 adults (≥18 years) with TGA and atrial switch surgery were followed at our adult congenital center since 1989. Four patients were excluded: two with double-outlet right ventricles and two with sub...
2 CitationsSource
#1Paul Khairy (MHI: Montreal Heart Institute)H-Index: 45
Abstract The expanding population of adults with congenital heart disease (CHD) combined with the pervasiveness of arrhythmias has resulted in the rapid growth of a dedicated sector of cardiology at the intersection between two subspecialties: electrophysiology and adult CHD. Herein, practical considerations are offered regarding urgent referral for catheter ablation of atrial arrhythmias, anticoagulation, and primary prevention implantable cardioverter-defibrillators (ICDs). Patients with Ebste...
Source
#1Rohit K. Kharbanda (EUR: Erasmus University Rotterdam)H-Index: 1
#2N. M. S. de Groot (EUR: Erasmus University Rotterdam)H-Index: 8
Source
#1Paul Khairy (MHI: Montreal Heart Institute)H-Index: 45
Source
#1Nayan T. Srivastava (Riley Hospital for Children)H-Index: 1
#2Roger A. Hurwitz (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 1
Last. Eric S. Ebenroth (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 1
view all 7 authors...
1 CitationsSource
#1Marie-A. Chaix (MHI: Montreal Heart Institute)H-Index: 4
#2Annie Dore (MHI: Montreal Heart Institute)H-Index: 25
Last. François-Pierre Mongeon (MHI: Montreal Heart Institute)H-Index: 17
view all 13 authors...
Abstract Background Echocardiographic evaluation of the systemic right ventricle (sRV) remains challenging in patients with transposition of the great arteries (TGA) corrected by an atrial switch (AS) and with congenitally corrected TGA (ccTGA). The aim of this study was to determine the interobserver and intraobserver variability of echocardiographic parameters for sRV size and systolic function. Methods Six independent observers retrospectively interpreted 44 previously acquired echocardiogram...
1 CitationsSource
#1Victor Waldmann (MHI: Montreal Heart Institute)H-Index: 2
#2Mikael Laredo (MHI: Montreal Heart Institute)H-Index: 2
Last. Paul Khairy (MHI: Montreal Heart Institute)H-Index: 45
view all 5 authors...
Abstract A convergence of epidemiological and clinical features has prompted a precipitous rise in the prevalence of atrial fibrillation (AF) in the expanding population of adults with congenital heart disease. Herein, we synthesize the current state of knowledge on epidemiological features, associated morbidities, and pathophysiological insights regarding AF in adults with congenital heart disease. Management issues are examined including surgical, pharmacological, and catheter-based therapies....
2 CitationsSource