Engineering and optimising deaminase fusions for genome editing
Abstract
Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineered programmable cytidine deaminases and test if we could introduce site-specific cytidine to thymidine transitions in the absence of targeted genomic lesions. Our programmable deaminases effectively convert...
Paper Details
Title
Engineering and optimising deaminase fusions for genome editing
Published Date
Nov 2, 2016
Journal
Volume
7
Issue
1
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