Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs
Abstract
Pigs with SCID can be a useful model in regenerative medicine, xenotransplantation, and cancer cell transplantation studies. Utilizing genome editing technologies such as CRISPR/Cas9 system allows us to generate genetically engineered pigs at a higher efficiency. In this study, we report generation and phenotypic characterization of IL2RG knockout female pigs produced through combination of CRISPR/Cas9 system and SCNT. As expected, pigs lacking...
Paper Details
Title
Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs
Published Date
Nov 3, 2016
Volume
14
Issue
1
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