Challenges in Predicting Protein-Protein Interactions from Measurements of Molecular Diffusivity
Abstract
Dynamic light scattering can be used to measure the diffusivity of a protein within a formulation. The dependence of molecular diffusivity on protein concentration (traditionally expressed in terms of the interaction parameter kD) is often used to infer whether protein-protein interactions are repulsive or attractive, resulting in solutions that are colloidally stable or unstable, respectively. However, a number of factors unrelated to...
Paper Details
Title
Challenges in Predicting Protein-Protein Interactions from Measurements of Molecular Diffusivity
Published Date
Nov 1, 2016
Journal
Volume
111
Issue
9
Pages
1831 - 1842
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