DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain
Abstract
Infection with human parvovirus B19 (B19V) has been associated with a myriad of illnesses, including erythema infectiosum (Fifth disease), hydrops fetalis, arthropathy, hepatitis, and cardiomyopathy, and also possibly the triggering of any number of different autoimmune diseases. B19V NS1 is a multidomain protein that plays a critical role in viral replication, with predicted nuclease, helicase, and gene transactivation activities. Herein, we...
Paper Details
Title
DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain
Published Date
Nov 17, 2016
Journal
Volume
55
Issue
47
Pages
6577 - 6593
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