Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy

Volume: 113, Issue: 46, Pages: 13120 - 13125
Published: Oct 31, 2016
Abstract
Significance We have found that long telomeres protect mice from genetic cardiac diseases analogous to those found in humans, such as Duchenne muscular dystrophy (DMD). Mice lacking dystrophin, similar to patients with DMD, exhibit only mild disease. In contrast, mice that lack dystrophin and have “humanized” telomere lengths ( mdx 4cv /mTR G2 ) fully manifest both the severe human skeletal muscle wasting and cardiac failure typical of DMD....
Paper Details
Title
Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy
Published Date
Oct 31, 2016
Volume
113
Issue
46
Pages
13120 - 13125
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