Adiposity, hypoxia and sleep apneas: from obesity to metabolic syndrome

Obesity is a major risk factor for cardio-metabolic events. Obesity is linked to adipocyte dysfunction of which hypoxia is one of the main effectors. The adipocyte dysfunc- tion causes local inflammation and fibrosis but also promote systemic inflammation and ectopic fat depots themselves implicated in the pathophysiology of cardiometabolic comor- bidities associated with obesity. The null or android distribution of the adipose tissue, usually...