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Effect of Surfactants and Thickeners on the Stability of Menthol-Diphenhydramine Cream Identified by Magnetic Resonance Imaging.

Published on Jan 1, 2016in Chemical & Pharmaceutical Bulletin1.405
· DOI :10.1248/cpb.c16-00562
Yoshinori Onuki15
Estimated H-index: 15
(University of Toyama),
Masamitsu Yokokawa1
Estimated H-index: 1
(Hoshi University)
+ 5 AuthorsKozo Takayama47
Estimated H-index: 47
(Hoshi University)
Abstract
  • References (21)
  • Citations (1)
References21
Newest
#1Yoshinori Onuki (University of Toyama)H-Index: 15
#2Chihiro Kida (Hoshi University)H-Index: 3
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 5 authors...
We have recently established a novel method to evaluate the emulsion stability of pharmaceutical skin cream. The key technology of the method is magnetic resonance imaging (MRI). The purpose of this study was to verify the usefulness of the method in the cosmetic industry.Milky lotion-type emulsions were employed as test samples. We note that the test samples were prepared by taking account of commercial milky lotions. After the sample preparation, a centrifugation treatment (5000 g for up to 12...
6 CitationsSource
#1Yoshinori Onuki (Hoshi University)H-Index: 15
#2Naoki Hasegawa (Hoshi University)H-Index: 2
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 8 authors...
The physical stability of pharmaceutical emulsions is an important quality attribute to be considered. To obtain a better understanding of this issue, this study investigated the contribution of the state of water to the physical stability of pharmaceutical emulsions. The key technology to evaluate the state of water was magnetic resonance imaging (MRI). For sample preparation, model emulsions with different formulation variables (surfactant content, water content, and hydrophilic-lipophilic bal...
4 CitationsSource
Xanthan gum is an extracellular polymer produced mainly by the bacterium Xanthomonas campestris. Traditionally it plays an important role in industrial applications as thickener, emulsion stabilizer and it has been added to water-based drilling fluids due to its pseudoplastic behavior and thermal stability. The structural properties of xanthan in solution can be tuned by the temperature and ionic strength; under high ionic strength or low temperature, xanthan chains are arranged in helical confo...
62 CitationsSource
#1Yoshinori Onuki (Hoshi University)H-Index: 15
#2Yoshiaki Machida (Hoshi University)H-Index: 6
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 6 authors...
4 CitationsSource
#1Yoshinori Onuki (Hoshi University)H-Index: 15
#2Chiaki Funatani (Hoshi University)H-Index: 2
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 8 authors...
8 CitationsSource
#1M. KowalskaH-Index: 1
#2M. MendryckaH-Index: 1
Last. S. StawarzH-Index: 1
view all 4 authors...
Synopsis Objective Formation of emulsion systems based on interesterified fats was the objective of the study. Enzymatic interesterification was carried out between enzymatic mutton tallow and walnut oil in the proportions 2 : 3 (w/w) to produce fats not available in nature. At the beginning of the interesterification process, the balance between the interesterification and fat hydrolysis was intentionally disturbed by adding more water to the catalyst (Lipozyme IR MR) of the reaction to produce...
5 CitationsSource
#1Yoshinori Onuki (Hoshi University)H-Index: 15
#2Akihiro HoritaH-Index: 2
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 6 authors...
AbstractA non-destructive method for monitoring creaming of emulsion-based formulations is in great demand because it allows us to understand fully their instability mechanisms. This study was aimed at demonstrating the usefulness of magnetic resonance (MR) techniques, including MR imaging (MRI) and MR spectroscopy (MRS), for evaluating the physicochemical stability of emulsion-based formulations. Emulsions that are applicable as the base of practical skin creams were used as test samples. Subst...
5 CitationsSource
#1Pornanong Aramwit (Chula: Chulalongkorn University)H-Index: 23
#2Orathai Keongamaroon (Chula: Chulalongkorn University)H-Index: 1
Last. Ouppatham SupasyndhH-Index: 12
view all 5 authors...
Background Uremic pruritus (UP) is a significant complication in ESRD patients and substantially impairs their quality of life. UP is considered to be a skin manifestation of chronic inflammation. Because sericin can suppress the release of pro-inflammatory cytokines, the purpose of this study was to investigate the short-term safety and efficacy of sericin cream for treating UP in hemodialysis patients.
23 CitationsSource
#1Manal HessienH-Index: 2
#2Nigel SinghH-Index: 1
Last. Eric ProuzetH-Index: 21
view all 4 authors...
We report on an analysis of the parameters that control both the stability and tunability of O/W nanoemulsions prepared by the phase inversion composition (PIC). These nanoemulsions are prepared with Tween 80 and Span 80, two nonionic surfactants, that can be mixed to adjust the hydrophilic lipophilic balance (HLB). We used a process mixture design method, which combines mixture and process design with phase diagrams, to describe the cross-link between parameters like composition, temperature of...
34 CitationsSource
#1Masato Nishikawa (Hoshi University)H-Index: 4
#2Yoshinori Onuki (Hoshi University)H-Index: 15
Last. Kozo Takayama (Hoshi University)H-Index: 47
view all 4 authors...
This study investigated the relationship between the state of water and the dispersion stability of a skin cream formulation. Hydrophilic ointments treated with a high-pressure wet-type jet mill were used as model formulations. Spin–lattice relaxation times (T1) were measured by magnetic resonance techniques to estimate the state of water in samples. A shorter T1 relaxation time was obtained from samples with higher surfactant content, whereas the processing pressure of the jet mill and 1-week s...
6 CitationsSource
Cited By1
Newest
#1Takahiro Tsuji (University of Toyama)H-Index: 1
#2Koji Mochizuki (Hoshi University)
Last. Yoshinori Onuki (University of Toyama)H-Index: 15
view all 7 authors...
Abstract The time–temperature superposition principle (TTSP) was applied to the destabilization kinetics of a pharmaceutical emulsion. The final goal of this study is to predict precisely the emulsion stability after long-term storage from the short-period accelerated test using TTSP. As the model emulsion, a cream preparation that is clinically used for the treatment of pruritus associated with chronic kidney disease was tested. After storage at high temperatures ranging from 30 to 45 °C for de...
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