A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development.
Abstract
During human brain development, multiple signaling pathways generate diverse cell types with varied regional identities. Here, we integrate single-cell RNA sequencing and clonal analyses to reveal lineage trees and molecular signals underlying early forebrain and mid/hindbrain cell differentiation from human embryonic stem cells (hESCs). Clustering single-cell transcriptomic data identified 41 distinct populations of progenitor, neuronal, and...
Paper Details
Title
A Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development.
Published Date
Jan 5, 2017
Journal
Volume
20
Issue
1
Pages
120 - 134
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