cGAS‐cGAMP‐STING: The three musketeers of cytosolic DNA sensing and signaling

Innate immunity is the first line of host defense against invading pathogens. The detection of aberrant nucleic acids which represent some conserved PAMPs triggers robust type I IFN‐mediated innate immune responses. Host‐ or pathogen‐derived cytosolic DNA binds and activates the DNA sensor cGAS, which synthesizes the second messenger 2′3′‐cGAMP and triggers STING‐dependent downstream signaling. Here, we highlight recent progress in...