Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy.
Abstract
Metastatic basal cell carcinomas are rare malignancies harbouring Hedgehog pathway alterations targetable by SMO antagonists (vismodegib/sonidegib). We describe, for the first time, the molecular genetics and response of a patient with Hedgehog inhibitor-resistant metastatic basal cell carcinoma who achieved rapid tumour regression (ongoing near complete remission at 4 months) with nivolumab (anti-PD1 antibody). He had multiple hallmarks of...
Paper Details
Title
Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy.
Published Date
Oct 19, 2016
Journal
Volume
1
Issue
1
Pages
16037
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