Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1
Abstract
Cells have evolved mechanisms to protect, restart and repair perturbed replication forks, allowing full genome duplication, even under replication stress. Interrogating the interplay between nuclease-helicase Dna2 and Holliday junction (HJ) resolvase Yen1, we find the Dna2 helicase activity acts parallel to homologous recombination (HR) in promoting DNA replication and chromosome detachment at mitosis after replication fork stalling. Yen1, but...
Paper Details
Title
Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1
Published Date
Oct 25, 2016
Journal
Volume
7
Issue
1
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