Break-induced telomere synthesis underlies alternative telomere maintenance
Abstract
Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10–15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (break-induced replisome) at telomeres or elsewhere in the mammalian genome is poorly understood. Here we define break-induced telomere...
Paper Details
Title
Break-induced telomere synthesis underlies alternative telomere maintenance
Published Date
Oct 19, 2016
Journal
Volume
539
Issue
7627
Pages
54 - 58
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