Candidate gene analysis of the fibrinogen phenotype reveals the importance of polygenic co-regulation
Abstract
Fibrinogen and its functional aspects have been linked to cardiovascular disease. There is vast discrepancy between the heritability of fibrinogen concentrations observed in twin studies and the heritability uncovered by genome wide association studies. We postulate that some of the missing heritability might be explained by the pleiotropic and polygenic co-regulation of fibrinogen through multiple targeted genes, apart from the fibrinogen genes...
Paper Details
Title
Candidate gene analysis of the fibrinogen phenotype reveals the importance of polygenic co-regulation
Published Date
Jul 1, 2017
Journal
Volume
60-61
Pages
16 - 26
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