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Deep fried edible oils disturb hepatic redox equilibrium and heightens lipotoxicity and hepatosteatosis in male Wistar rats.

Published on Sep 1, 2017in Human & Experimental Toxicology2.171
· DOI :10.1177/0960327116674530
Arunaksharan Narayanankutty9
Estimated H-index: 9
(University of Calicut),
Jeksy Jos Manalil5
Estimated H-index: 5
(University of Calicut)
+ 6 AuthorsAchuthan C. Raghavamenon6
Estimated H-index: 6
(University of Calicut)
Abstract
Hepatosteatosis is a complex disorder, in which insulin resistance and associated dyslipidemic and inflammatory conditions are fundamental. Dietary habit, especially regular consumption of fat and sugar-rich diet, is an important risk factor. Coconut and mustard oils (CO and MO) are medium-chain saturated and monounsaturated fats that are common dietary ingredients among the Indian populations. Present study analyzed the effect of prolonged consumption of the fresh and thermally oxidized forms of these oils on glucose tolerance and hepatosteatosis in male Wistar rats. Thermally oxidized CO (TCO) and MO (TMO) possessed higher amount of lipid peroxidation products and elevated p-anisidine values than their fresh forms. Dietary administration of TCO and TMO along with fructose altered glucose tolerance and increased hyperglycemia in rats. Dyslipidemia was evident by elevated levels of triglycerides and reduced high density lipoprotein cholesterol (HDLc) levels in fructose and edible oil-fed group (p < 0.05)....
  • References (48)
  • Citations (10)
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References48
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#1Gitanjali Singh (Tufts University)H-Index: 11
#1Gitanjali M. Singh (Tufts University)H-Index: 21
Last. Dariush Mozaffarian (Tufts University)H-Index: 122
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Autier and colleagues suggest that disease burdens attributable to individual dietary factors such as sugar-sweetened beverages (SSBs) are unquantifiable. Decades of robust research have established methods to evaluate population-health impacts of modifiable risk factors as diverse as air pollution, smoking, blood pressure, and poor diet.1 We agree that such factors often cluster: Like any other cause of disease, SSB consumption combines with multiple factors to characterize individuals’ lifesty...
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#1Arunaksharan Narayanankutty (University of Calicut)H-Index: 9
#2Reshma K. Mukesh (University of Calicut)H-Index: 1
Last. Achuthan C. Raghavamenon (University of Calicut)H-Index: 6
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26 CitationsSource
#1Ryan Richard Ruff (NYU: New York University)H-Index: 8
Commentary on: Singh GM, Micha R, Khatibzadeh S, et al., Global Burden of Diseases Nutrition and Chronic Diseases Expert Group (NutriCoDE). Estimated global, regional, and national disease burdens related to sugar-sweetened beverage consumption in 2010. Circulation 2015;132:639–66[OpenUrl][1][Abstract/FREE Full Text][2]. Obesity and obesity-related non-communicable diseases are global health burdens associated with all-cause and cause-specific mortality, economic costs and impaired quality of li...
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#1Vishal Singh (Central Drug Research Institute)H-Index: 20
#2Manish Jain (Central Drug Research Institute)H-Index: 15
Last. Manoj Kumar Barthwal (Central Drug Research Institute)H-Index: 23
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Background & objectives: Curcuma oil (C. oil) isolated from turmeric (Curcuma longa L.) has been shown to have neuro-protective, anti-cancer, antioxidant and anti-hyperlipidaemic effects in experimental animal models. However, its effect in insulin resistant animals remains unclear. The present study was carried out to investigate the disease modifying potential and underlying mechanisms of the C. oil in animal models of diet induced insulin resistance and associated thrombotic complications. Me...
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This study was conducted to investigate the effects of dietary coconut oil as a medium-chain fatty acid (MCFA) source on performance, carcass composition and serum lipids in male broilers. A total of 540, one-day-old, male Arbor Acres broilers were randomly allotted to 1 of 5 treatments with each treatment being applied to 6 replicates of 18 chicks. The basal diet (i.e., R0) was based on corn and soybean meal and was supplemented with 1.5% soybean oil during the starter phase (d 0 to 21) and 3.0...
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Abstract This study investigates the possible protective effects of levocetirizine against fructose-induced insulin resistance, hepatic steatosis and vascular dysfunction, in comparison to pioglitazone, a standard insulin sensitizer. Male Sprague Dawley rats (150–200 g) were divided into 4 groups. Three groups were fed on high fructose diets (HFD) containing 60% w/w fructose, while the fourth control group was fed on standard laboratory food for 8 weeks. AUC OGTT , AUC ITT , fasting glucose, HOM...
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#1Prem Prakash (Central Drug Research Institute)H-Index: 13
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Abstract High dietary fructose causes insulin resistance syndrome (IRS), primarily due to simultaneous induction of genes involved in glucose, lipid and mitochondrial oxidative metabolism. The present study evaluates effect of a hepatoprotective agent, silymarin (SYM) on fructose-induced metabolic abnormalities in the rat and also assessed the associated thrombotic complications. Wistar rats were kept on high fructose (HFr) diet throughout the 12-week study duration (9 weeks of HFr feeding and s...
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#1Firoozeh Nafar (MUN: Memorial University of Newfoundland)H-Index: 4
#2Karen M. Mearow (MUN: Memorial University of Newfoundland)H-Index: 19
Dietary supplementation has been studied as an approach to ameliorating deficits associated with aging and neurode- generation. We undertook this pilot study to investigate the effects of coconut oil supplementation directly on cortical neurons treated with amyloid- (A) peptide in vitro. Our results indicate that neuron survival in cultures co-treated with coconut oil and A is rescued compared to cultures exposed only to A. Coconut oil co-treatment also attenuates A-induced mitochondrial alterat...
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#1Rachel J. Perry (Yale University)H-Index: 21
#2Taehan Kim (Yale University)H-Index: 5
Last. Gerald I. ShulmanH-Index: 148
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Summary Nonalcoholic fatty liver disease (NAFLD) affects one in three Americans and is a major predisposing condition for the metabolic syndrome and type 2 diabetes (T2D). We examined whether a functionally liver-targeted derivative of 2,4-dinitrophenol (DNP), DNP-methyl ether (DNPME), could safely decrease hypertriglyceridemia, NAFLD, and insulin resistance without systemic toxicities. Treatment with DNPME reversed hypertriglyceridemia, fatty liver, and whole-body insulin resistance in high-fat...
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Nonalcoholic fatty liver disease is the most frequent liver disease. Ezetimibe, an inhibitor of intestinal cholesterol absorption, has been reported to ameliorate hepatic steatosis in human and animal models. To explore how ezetimibe reduces hepatic steatosis, we investigated the effects of ezetimibe on the expression of lipogenic enzymes and intestinal lipid metabolism in mice fed a high-fat or a high-fructose diet. CBA/JN mice were fed a high-fat diet or a high-fructose diet for 8 wk with or w...
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Virgin coconut oil (VCO) and turmeric are traditionally being used in Indian cuisine systems; VCO is a natural combination of medium-chain triglyceride and polyphenols with established pharmacological potential. Curcumin isolated from turmeric is renowned for its anticancer properties, however, with limited clinical success due to poor bioavailability. Considering the lipophilic nature of VCO, curcumin added to VCO is expected to have synergistic/additive actions. In this study, the chemoprevent...
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#1Pan Zhuang (ZJU: Zhejiang University)H-Index: 6
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BACKGROUND: Evidence suggests that the relations between intakes of individual fatty acids and risk of type 2 diabetes (T2D) vary. However, associations between intakes of different cooking oils as sources of fatty acids and incident T2D remain largely unknown. OBJECTIVES: We aimed to evaluate relations between intakes of individual cooking oils and incident T2D in a nationwide Chinese cohort. METHODS: Overall 15,022 Chinese adults aged >/=20 y from the China Health and Nutrition Survey (CHNS) w...
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: Nature is a rich source of natural drug-like compounds with almost zero side effects. Phytochemicals better known as "Natural Products" are found abundantly in a number of plants. Since time immemorial, spices have been widely used in Indian cuisine as flavoring and colouring agents. Most of these spices and condiments are derived from various biodiversity hotspots in India (which contributes 75% of global spice production) and form the crux of India's multidiverse and multicultural cuisine. A...
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Abstract Thermal oxidation products of edible oils including aldehydes, peroxides and polymerized triglycerides formed during the cooking process are increasingly debated as contributory to chronic degenerative diseases. Depending on the oil used for cooking, the source of fatty acids and its oxidation products may vary and would have a differential influence on the physiological process. Coconut oil (CO) is a medium chain triglyceride-rich edible oil used in South India and other Asia Pacific c...
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Abstract Background Edible oils, preferably plant origin are rich sources of fatty acids and other lipophilic antioxidants to the body. Among these, oils derived from the coconut kernel (Cocos nucifera) are widely used in India and the Asia Pacific, which includes copra oil (CO), virgin coconut oil (VCO) and refined, bleached and deodorized (RBD) oil. Based on the mode of preparation, their composition and biological effects vary. Scope and approach This review compares the physicochemical and b...
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#1Devi Lekshmi Sheela (Kerala Agricultural University)H-Index: 1
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Abstract Coconut oil (CO), the primary choice of cooking purposes in the south Asian countries, is rich in medium chain saturated fatty acids, especially lauric acid (50–52%). The oil has high medicinal use in Ayurvedic system and known to contain polyphenolic antioxidants. Studies have reported that CO improves insulin sensitivity and shows hypoglycemic effect. However, there is no information regarding its effect on chronic diabetic complications including retinopathy and nephropathy is availa...
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