Deep fried edible oils disturb hepatic redox equilibrium and heightens lipotoxicity and hepatosteatosis in male Wistar rats

Published on Sep 1, 2017in Human & Experimental Toxicology2.17
· DOI :10.1177/0960327116674530
Arunaksharan Narayanankutty6
Estimated H-index: 6
(University of Calicut),
Jj Manalil4
Estimated H-index: 4
(University of Calicut)
+ 6 AuthorsAchuthan C. Raghavamenon5
Estimated H-index: 5
(University of Calicut)
Hepatosteatosis is a complex disorder, in which insulin resistance and associated dyslipidemic and inflammatory conditions are fundamental. Dietary habit, especially regular consumption of fat and sugar-rich diet, is an important risk factor. Coconut and mustard oils (CO and MO) are medium-chain saturated and monounsaturated fats that are common dietary ingredients among the Indian populations. Present study analyzed the effect of prolonged consumption of the fresh and thermally oxidized forms of these oils on glucose tolerance and hepatosteatosis in male Wistar rats. Thermally oxidized CO (TCO) and MO (TMO) possessed higher amount of lipid peroxidation products and elevated p-anisidine values than their fresh forms. Dietary administration of TCO and TMO along with fructose altered glucose tolerance and increased hyperglycemia in rats. Dyslipidemia was evident by elevated levels of triglycerides and reduced high density lipoprotein cholesterol (HDLc) levels in fructose and edible oil-fed group (p < 0.05)....
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#1Vishal Singh (Central Drug Research Institute)H-Index: 16
#2Manish Jain (Central Drug Research Institute)H-Index: 14
Last.Manoj Kumar Barthwal (Central Drug Research Institute)H-Index: 21
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#1Prem Prakash (Central Drug Research Institute)H-Index: 12
#2Vishal Singh (Central Drug Research Institute)H-Index: 16
Last.Madhu Dikshit (Central Drug Research Institute)H-Index: 33
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#1Firoozeh Nafar (MUN: Memorial University of Newfoundland)H-Index: 4
#2Karen M. Mearow (MUN: Memorial University of Newfoundland)H-Index: 19
#1Masateru Ushio (Shiga University of Medical Science)H-Index: 1
#2Yoshihiko Nishio (Kadai: Kagoshima University)H-Index: 39
Last.Atsunori Kashiwagi (Shiga University of Medical Science)H-Index: 65
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