IC-P-134: Differentiating Preclinical Alzheimer’s Disease from Normal Aging: The Effects of Age and Amyloid on Cognitive Decline Over 3.5 Years

Autopsy and amyloid PET imaging studies have consistently demonstrated that amyloid pathology is present in many non-demented older adults. Consequently, it has become critical to differentiate normal age-related cognitive decline from decline due to AD pathology. To help disentangle these two processes, we examined the effects of age and amyloid deposition on 3.5-year longitudinal cognitive changes across multiple domains in healthy adults,...