Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit

Significance The pathogenic trypanosomatids— Trypanosoma cruzi , Trypanosoma brucei , and Leishmania spp.—are the causative agents of Chagas disease, African trypanosomiasis, and leishmaniasis, respectively. These diseases, with high morbidity and mortality rates, affect millions of people worldwide. Current treatments typically use drugs with high toxicity and marginal efficacy. Here we present, a 2.5-Å structure of the T. cruzi ribosome large...