Hypermutation In Pancreatic Cancer
Abstract
Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation burden and defective DNA repair are associated with response to immune checkpoint inhibitors in several other cancer types. We interrogated 385 pancreatic cancer genomes to define hypermutation and its causes. Mutational signatures inferring defects in DNA repair were enriched in those with the highest mutation burdens. Mismatch repair deficiency was...
Paper Details
Title
Hypermutation In Pancreatic Cancer
Published Date
Jan 1, 2017
Journal
Volume
152
Issue
1
Pages
68 - 74.e2
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