Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex
Abstract
The Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex orchestrates the cellular response to DSBs through its structural, enzymatic, and signaling roles. Xrs2/Nbs1 is essential for nuclear translocation of Mre11, but its role as a component of the complex is not well defined. Here, we demonstrate that nuclear localization of Mre11 (Mre11-NLS) is able to bypass several functions of Xrs2, including DNA end resection, meiosis, hairpin resolution, and cellular...
Paper Details
Title
Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex
Published Date
Oct 1, 2016
Journal
Volume
64
Issue
2
Pages
405 - 415
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