Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
Abstract
Macrophages play crucial roles in host defence and tissue homoeostasis, processes in which both environmental stimuli and intracellularly generated metabolites influence activation of macrophages. Activated macrophages are classified into M1 and M2 macrophages. It remains unclear how intracellular nutrition sufficiency, especially for amino acid, influences on macrophage activation. Here we show that a lysosomal adaptor protein Lamtor1, which...
Paper Details
Title
Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
Published Date
Oct 12, 2016
Journal
Volume
7
Issue
1
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