A pilot study of the effects of niacin administration on free fatty acid and growth hormone concentrations in children with obesity

Children with obesity have low spontaneous growth hormone (GH) secretion. High circulating free fatty acid (FFA) concentration is believed to inhibit GH secretion in those with obesity. In adults, lipolytic inhibition with niacin lowers FFA and increases GH, but there are no prior studies in children with obesity.The objective of the study was to determine the dose and frequency of niacin administration required to lower FFA and stimulate GH in...