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Checkpoints for autoimmunity-induced heart tissue damage in human Chagas disease A multistep process?

Published on Jul 12, 1998
Edecio Cunha Neto4
Estimated H-index: 4
,
Lúcia Cristina Jamli Abel2
Estimated H-index: 2
+ 6 AuthorsJorge Kalil4
Estimated H-index: 4
Abstract
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  • Citations (5)
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Cited By5
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#1Edecio Cunha-Neto (USP: University of São Paulo)H-Index: 38
#2Angelina M. BilateH-Index: 17
Last. David M. Engman (NU: Northwestern University)H-Index: 39
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Up to 18 million of individuals are infected by the protozoan parasite Trypanosoma cruzi in Latin America, one third of whom will develop chronic Chagas disease cardiomyopathy (CCC) up to 30 years after infection. Cardiomyocyte destruction is associated with a T cell-rich inflammatory infiltrate and fibrosis. The presence of such lesions in the relative scarcity of parasites in the heart, suggested that CCC might be due, in part, to a postinfectious autoimmune process. Over the last two decades,...
99 CitationsSource
#1Edecio Cunha-NetoH-Index: 38
#2Leo K. IwaiH-Index: 17
Last. Jorge KalilH-Index: 4
view all 5 authors...
Chronic Chagas' Disease Cardiomyopathy (CCC) is one of the few well-defined examples of human post-infectious autoimmunity, as documented by several groups in over 50 publications. The time scale dissociation between primary infection with high tissue and blood parasitism and tissue pathology, allied to the scarcity of T. cruzi in CCC heart lesions prompted investigators as early as 70 years ago to suggest that the mononuclear cell infiltrate should directly damage the heart in an autoimmune fas...
14 CitationsSource
#1Leo K. Iwai (USP: University of São Paulo)H-Index: 17
#2Márcia A. Duranti (USP: University of São Paulo)H-Index: 4
Last. Edecio Cunha-Neto (USP: University of São Paulo)H-Index: 38
view all 7 authors...
Abstract Retro inverso (RI) analogues of antigenic synthetic peptides, which are made of D-amino acids with a reversed sequence, may mimic the side chain conformation of natural all-L peptides. RI analogues were cross-reactively recognized by antibodies and CD4+ T cells reactive against natural all-L synthetic peptides or native proteins in animal models. Since peptides containing D-amino acids are highly resistant to proteolytic digestion, cross-reactive RI analogues may be ideal for in vivo ad...
16 CitationsSource
#1Edecio Cunha-Neto (USP: University of São Paulo)H-Index: 38
#2Jorge Kalil (HHMI: Howard Hughes Medical Institute)H-Index: 48
Heart tissue destruction in chronic Chagas' disease cardiomyopathy (CCC), occurring in 30% of individuals chronically infected by the protozoan parasite Trypanosoma cruzi, may be caused by autoimmune recognition of patients' heart tissue by a T cell rich inflammatory infiltrate. Recently, our group demonstrated that T cells infiltrating the heart of CCC patients crossreactively recognize cardiac myosin heavy chain and tandemly repetitive T. cruzi antigen B13, and possess an inflammatory T1 -type...
41 CitationsSource
#1Edecio Cunha-Neto (USP: University of São Paulo)H-Index: 38
#2Jorge Kalil (HHMI: Howard Hughes Medical Institute)H-Index: 48
Chronic Chagas' disease cardiomyopathy (CCC) is one of the few well-defined examples of human postinfectious autoimmunity in which an infectious episode with an established pathogen—the protozoan parasite Trypanosoma cruzi—clearly triggers autoimmune phenomena, most of which are related to documented molecular mimicry and organ-specific damage. Unraveling of the relationship by which molecular mimicry between an infectious agent and self-components can trigger organ-specific autoimmunity may lea...
6 CitationsSource