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Considerations for Developing a Zika Virus Vaccine

Published on Sep 29, 2016in The New England Journal of Medicine 70.67
· DOI :10.1056/NEJMp1607762
Hilary D. Marston10
Estimated H-index: 10
Nicole Lurie52
Estimated H-index: 52
+ 1 AuthorsAnthony S. Fauci169
Estimated H-index: 169
The scientific feasibility of developing a safe, effective Zika vaccine doesn't ensure successful development. An efficient development pathway must be delineated, including better ways to evaluate vaccine candidates for intended target populations.
  • References (3)
  • Citations (35)
Published on Nov 1, 2016in Nature Communications 11.88
Dawn M. Dudley15
Estimated H-index: 15
Matthew T. Aliota21
Estimated H-index: 21
+ 24 AuthorsChristina M. Newman11
Estimated H-index: 11
Animal models of infection with Zika virus (ZIKV) are urgently needed for a better understanding of pathogenesis and for testing potential therapies. Here, the authors describe infection of rhesus macaques with an Asian-lineage ZIKV strain as a relevant animal model for studying ZIKV pathogenesis.
Published on Jun 11, 2009in The New England Journal of Medicine 70.67
Mark R. Duffy7
Estimated H-index: 7
T Chen1
Estimated H-index: 1
(CDC: Centers for Disease Control and Prevention)
+ 17 AuthorsChristine Dubray1
Estimated H-index: 1
Background In 2007, physicians on Yap Island reported an outbreak of illness characterized by rash, conjunctivitis, and arthralgia. Although serum from some patients had IgM antibody against dengue virus, the illness seemed clinically distinct from previously detected dengue. Subsequent testing with the use of consensus primers detected Zika virus RNA in the serum of the patients but no dengue virus or other arboviral RNA. No previous outbreaks and only 14 cases of Zika virus disease have been p...
Published on Oct 1, 2001in Clinical Infectious Diseases 9.05
G. Miller Franklin1
Estimated H-index: 1
(NIH: National Institutes of Health),
Christine Grady39
Estimated H-index: 39
(NIH: National Institutes of Health)
Challenge experiments that induce infections in healthy volunteers are an important method for initial efficacy testing of candidate vaccines and for study of the pathogenesis of infectious diseases. Although these studies can be conducted safely for selected infectious diseases that are either fully treatable or self-limiting, they raise significant ethical issues. An ethical framework is offered for evaluating infection-inducing challenge experiments, which focuses on the scientific and public...
Cited By35
Published on Apr 26, 2019in Nature Communications 11.88
Supriya Ravichandran1
Estimated H-index: 1
(CBER: Center for Biologics Evaluation and Research),
Megan Hahn1
Estimated H-index: 1
(CBER: Center for Biologics Evaluation and Research)
+ 8 AuthorsJohn H. Beigel16
Estimated H-index: 16
Zika virus (ZIKV) outbreak in Americas led to extensive efforts to develop vaccines and ZIKV-specific diagnostics. In the current study, we use whole genome phage display library spanning the entire ZIKV genome (ZIKV-GFPDL) for in-depth immune profiling of IgG and IgM antibody repertoires in serum and urine longitudinal samples from individuals acutely infected with ZIKV. We observe a very diverse IgM immune repertoire encompassing the entire ZIKV polyprotein on day 0 in both serum and urine. ZI...
Published on Apr 7, 2019in Tropical Medicine and Infectious Disease
In-Jeong Kim11
Estimated H-index: 11
Marcia A. Blackman43
Estimated H-index: 43
Jr-Shiuan Lin8
Estimated H-index: 8
Zika virus (ZIKV) infection during pregnancy can result in a variety of developmental abnormalities in the fetus, referred to as Congenital Zika Syndrome (CZS). The effects of CZS can range from the loss of the viable fetus to a variety of neurological defects in full-term infants, including microcephaly. The clinical importance of ZIKV-induced CZS has driven an intense effort to develop effective vaccines. Consequently, there are approximately 45 different ZIKV vaccine candidates at various sta...
Published on Dec 1, 2018
Alan D. T. Barrett61
Estimated H-index: 61
Zika virus (ZIKV), a mosquito-borne flavivirus, was first identified in the 1940s in Uganda in Africa and emerged in the Americas in Brazil in May 2015. In the 30 months since ZIKV emerged as a major public health problem, spectacular progress has been made with vaccine development cumulating with the publication of three reports of phase 1 clinical trials in the 4th quarter of 2017. Clinical trials involving candidate DNA and purified inactivated virus vaccines showed all were safe and well-tol...
Published on Dec 1, 2018in Journal of the Neurological Sciences 2.65
Oscar Mancera-Páez1
Estimated H-index: 1
(National University of Colombia),
Gustavo C. Román15
Estimated H-index: 15
+ 2 AuthorsJuan-Manuel Anaya54
Estimated H-index: 54
(Del Rosario University)
Abstract We review post-infectious and post-vaccination neurological syndromes involving peripheral and central nervous system (CNS) and report an illustrative case of simultaneous occurrence of Guillain-Barre syndrome (GBS), confirmed by nerve conduction velocities, plus MRI-demonstrated transverse myelitis (TM) and acute encephalitis [acute disseminated encephalomyelitis] (ADEM+GBS) affecting a 24-year-old woman from Cucuta, Colombia, who developed acute Zika virus (ZIKV) infection confirmed b...
Published on Jun 22, 2018in Science 41.04
S. K. Shah1
Estimated H-index: 1
(Seattle Children's Research Institute),
Jonathan Kimmelman24
Estimated H-index: 24
(McGill University)
+ 5 AuthorsC. Zorrilla1
Estimated H-index: 1
(UPR: University of Puerto Rico)
Krause and Gruber offer the U.S. Food and Drug Administration (FDA) as part of the solution to the problems we have identified. We agree that the FDA could helpfully assist with the review of specific protocols for Zika human challenge trials (HCTs), especially given the need to update our panel's
Published on Jun 1, 2018in Acta Tropica 2.63
José V.J. Silva2
Estimated H-index: 2
(FIOCRUZ: Oswaldo Cruz Foundation),
Thaísa Regina Rocha Lopes3
Estimated H-index: 3
(UFPE: Federal University of Pernambuco)
+ 3 AuthorsLaura H.V.G. Gil19
Estimated H-index: 19
(FIOCRUZ: Oswaldo Cruz Foundation)
Abstract Emerging and re-emerging viral infections transmitted by insect vectors (arthopode-borne viruses, arbovirus) are a serious threat to global public health. Among them, yellow fever (YFV), dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses are particularly important in tropical and subtropical regions. Although vector control is one of the most used prophylactic measures against arboviruses, it often faces obstacles, such as vector diversity, uncontrolled urbanization and increasi...
Published on May 1, 2018in Cell Reports 7.82
Cui Li4
Estimated H-index: 4
(CAS: Chinese Academy of Sciences),
Fei Gao3
Estimated H-index: 3
(THU: Tsinghua University)
+ 8 AuthorsZhenkang Xu30
Estimated H-index: 30
(CAS: Chinese Academy of Sciences)
Summary Zika virus (ZIKV) is a mosquito-transmitted flavivirus that is generally benign in humans. However, an emergent strain of ZIKV has become widespread, causing severe pre- and post-natal neurological defects. There is now an urgent need for prophylactic and therapeutic agents. To address this, we investigated six human monoclonal antibodies with ZIKV epitope specificity and neutralizing activity in mouse models of ZIKV infection and microcephaly. A single intraperitoneal injection of these...
Published on May 1, 2018in Journal of Medical Ethics 2.19
Euzebiusz Jamrozik2
Estimated H-index: 2
Michael J. Selgelid14
Estimated H-index: 14
(Monash University)
Zika virus was recognised in 2016 as an important vector-borne cause of congenital malformations and Guillain-Barre syndrome, during a major epidemic in Latin America, centred in Northeastern Brazil. The WHO and Pan American Health Organisation (PAHO), with partner agencies, initiated a coordinated global response including public health intervention and urgent scientific research, as well as ethical analysis as a vital element of policy design. In this paper, we summarise the major ethical issu...