Original paper
Lyso-Sulfatide Binds Factor Xa and Potently Inhibits Thrombin Generation.
Abstract
1130 Although phospholipids are well-recognized for their effects on coagulation reactions, little is generally known about the effects of sphingolipids on clotting pathways. Negatively-charged sulfatides can potently initiate the intrinsic pathway of coagulation system by binding and autoactivating factor (f) XII. Sphingosine potently inhibits the ability of factor Xa (fXa) to generate thrombin (fIIa) in the prothrombinase complex (II-ase)...
Paper Details
Title
Lyso-Sulfatide Binds Factor Xa and Potently Inhibits Thrombin Generation.
Published Date
Nov 19, 2010
Journal
Volume
116
Issue
21
Pages
1130 - 1130
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Notes
History