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Dietary Fat and Risk of Cardiovascular Disease: Recent Controversies and Advances

Published on Aug 21, 2017in Annual Review of Nutrition 8.89
· DOI :10.1146/annurev-nutr-071816-064614
Dong D. Wang19
Estimated H-index: 19
,
Frank B. Hu202
Estimated H-index: 202
Abstract
Health effects of dietary fats have been extensively studied for decades. However, controversies exist on the effects of various types of fatty acids, especially saturated fatty acid (SFA), on cardiovascular disease (CVD). Current evidence supports that different types of dietary fatty acids have divergent effects on CVD risk, and the effects also depend strongly on the comparison or replacement macronutrient. A significant reduction in CVD risk can be achieved if SFAs are replaced by unsaturated fats, especially polyunsaturated fatty acids. Intake of industrially produced trans fat is consistently associated with higher CVD risk. Both n-6 and n-3 polyunsaturated fatty acids are associated with lower CVD risk, although the effects of fish oil supplementation remains inconsistent. The 2015–2020 Dietary Guidelines for Americans place greater emphasis on types of dietary fat than total amount of dietary fat and recommend replacing SFAs with unsaturated fats, especially polyunsaturated fatty acids for CVD pre...
  • References (151)
  • Citations (21)
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References151
Newest
Published on Apr 1, 2017in Clinical Nutrition 5.50
Susanna C. Larsson61
Estimated H-index: 61
(KI: Karolinska Institutet),
Alicja Wolk110
Estimated H-index: 110
(KI: Karolinska Institutet)
Summary Background & aims Whether high intakes of fish and long-chain omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of atrial fibrillation (AF) remains uncertain. Thus, we aimed to evaluate the associations of total fish, types of fish, and omega-3 PUFA intake with AF incidence in a large prospective study. Methods We used data from the Cohort of Swedish Men and the Swedish Mammography Cohort to examine the associations of fish consumption and long-chain omega-3 PUFA intake with AF...
6 Citations Source Cite
Published on Nov 23, 2016in BMJ 23.56
Geng Zong16
Estimated H-index: 16
(Harvard University),
Yanping Li43
Estimated H-index: 43
(Harvard University)
+ 5 AuthorsQi Sun62
Estimated H-index: 62
(Harvard University)
Objectives To investigate the association between long term intake of individual saturated fatty acids (SFAs) and the risk of coronary heart disease, in two large cohort studies. Design Prospective, longitudinal cohort study. Setting Health professionals in the United States. Participants 73 147 women in the Nurses’ Health Study (1984-2012) and 42 635 men in the Health Professionals Follow-up Study (1986-2010), who were free of major chronic diseases at baseline. Main outcome measure Incidence o...
49 Citations Source Cite
Published on Nov 1, 2016in The American Journal of Clinical Nutrition 6.55
Mu Chen10
Estimated H-index: 10
(Harvard University),
Yanping Li43
Estimated H-index: 43
+ 6 AuthorsFrank B. Hu202
Estimated H-index: 202
(Harvard University)
42 Citations Source Cite
Published on Aug 1, 2016in JAMA Internal Medicine 19.99
Dong D. Wang19
Estimated H-index: 19
(Harvard University),
Yanping Li43
Estimated H-index: 43
(Harvard University)
+ 5 AuthorsFrank B. Hu202
Estimated H-index: 202
(Harvard University)
Importance Previous studies have shown distinct associations between specific dietary fat and cardiovascular disease. However, evidence on specific dietary fat and mortality remains limited and inconsistent. Objective To examine the associations of specific dietary fats with total and cause-specific mortality in 2 large ongoing cohort studies. Design, Setting, and Participants This cohort study investigated 83 349 women from the Nurses’ Health Study (July 1, 1980, to June 30, 2012) and 42 884 me...
117 Citations Source Cite
Published on Aug 1, 2016in JAMA Internal Medicine 19.99
Liana C. Del Gobbo21
Estimated H-index: 21
(Stanford University),
Fumiaki Imamura27
Estimated H-index: 27
(Medical Research Council)
+ 46 AuthorsAlexis C. Frazier-Wood25
Estimated H-index: 25
(BCM: Baylor College of Medicine)
Importance The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than biomarkers. Objective To evaluate biomarkers of seafood-derived eicosapentaenoic acid (EPA; 20:5ω-3), docosapentaenoic acid (DPA; 22:5ω-3), and docosahexaenoic acid (DHA; 22:6ω-3) and plant-derived α-linolenic acid (ALA; 18:3ω-3) for incident CHD. Data Sources A global consortium of 19 ...
106 Citations Source Cite
Published on Jun 7, 2016in JAMA 47.66
Katherine M. Flegal83
Estimated H-index: 83
(CDC: Centers for Disease Control and Prevention),
Deanna Kruszon-Moran33
Estimated H-index: 33
(CDC: Centers for Disease Control and Prevention)
+ 2 AuthorsCynthia L. Ogden55
Estimated H-index: 55
(CDC: Centers for Disease Control and Prevention)
Importance Between 1980 and 2000, the prevalence of obesity increased significantly among adult men and women in the United States; further significant increases were observed through 2003-2004 for men but not women. Subsequent comparisons of data from 2003-2004 with data through 2011-2012 showed no significant increases for men or women. Objective To examine obesity prevalence for 2013-2014 and trends over the decade from 2005 through 2014 adjusting for sex, age, race/Hispanic origin, smoking s...
955 Citations Source Cite
Published on Jun 1, 2016in Journal of Stroke & Cerebrovascular Diseases 1.60
Pengfei Cheng2
Estimated H-index: 2
(Jiamusi University),
Jingxia Wang2
Estimated H-index: 2
(Jiamusi University),
Weihua Shao9
Estimated H-index: 9
(CQMU: Chongqing Medical University)
Background We performed a meta-analysis aiming to clarify the relationship between monounsaturated fatty acid (MUFA) intake and stroke risk. Methods Relevant studies were identified by searching relevant databases through January 2016. We included cohort studies that reported relative risks (RRs) with 95% confidence intervals (CIs) for the association between MUFA intake and stroke risk. A random-effects model was used to derive composite RR estimates for stroke. Results Ten prospective cohort s...
11 Citations Source Cite
Published on Apr 26, 2016in Circulation 18.88
Mohammad Yawar Yakoob26
Estimated H-index: 26
,
Peilin Shi29
Estimated H-index: 29
+ 5 AuthorsDariush Mozaffarian113
Estimated H-index: 113
Background—In prospective studies, the relationship of self-reported consumption of dairy foods with risk of diabetes mellitus is inconsistent. Few studies have assessed dairy fat, using circulating biomarkers, and incident diabetes mellitus. We tested the hypothesis that circulating fatty acid biomarkers of dairy fat, 15:0, 17:0, and t-16:1n-7, are associated with lower incident diabetes mellitus. Methods and Results—Among 3333 adults aged 30 to 75 years and free of prevalent diabetes mellitus ...
37 Citations Source Cite
Published on Apr 12, 2016in BMJ 23.56
Christopher E. Ramsden16
Estimated H-index: 16
(UNC: University of North Carolina at Chapel Hill),
Daisy Zamora11
Estimated H-index: 11
(UNC: University of North Carolina at Chapel Hill)
+ 7 AuthorsJoseph R. Hibbeln46
Estimated H-index: 46
(NIH: National Institutes of Health)
Objective To examine the traditional diet-heart hypothesis through recovery and analysis of previously unpublished data from the Minnesota Coronary Experiment (MCE) and to put findings in the context of existing diet-heart randomized controlled trials through a systematic review and meta-analysis. Design The MCE (1968-73) is a double blind randomized controlled trial designed to test whether replacement of saturated fat with vegetable oil rich in linoleic acid reduces coronary heart disease and ...
114 Citations Source Cite
Published on Apr 1, 2016in European Heart Journal 23.43
Marcus E. Kleber47
Estimated H-index: 47
(Heidelberg University),
Graciela Delgado21
Estimated H-index: 21
(Heidelberg University)
+ 2 AuthorsClemens von Schacky26
Estimated H-index: 26
(LMU: Ludwig Maximilian University of Munich)
Aims Trans -fatty acids (TFAs) are generated by the food industry and also occur naturally in trace amounts in dairy products. For the latter, beneficial health effects have been claimed, while there are numerous reports about TFA of industrial origin being hazardous to human health. Therefore, we aimed to investigate the association of TFA with mortality in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Methods and results The fatty acid composition of erythrocyte membranes was ...
46 Citations Source Cite
Cited By21
Newest
Published on Jun 1, 2019in Social Marketing Quarterly
Robert John16
Estimated H-index: 16
(University of Oklahoma Health Sciences Center),
Karla Jaye Finnell2
Estimated H-index: 2
(University of Oklahoma Health Sciences Center)
+ 1 AuthorsStephanie M. DeBerry (University of Oklahoma Health Sciences Center)
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Published on May 4, 2019in Epigenetics 4.92
Mirian Samblas4
Estimated H-index: 4
(University of Navarra),
Fermín I. Milagro39
Estimated H-index: 39
(University of Navarra),
Alfredo Martínez
ABSTRACTThe fact that not all individuals exposed to the same environmental risk factors develop obesity supports the hypothesis of the existence of underlying genetic and epigenetic elements. There is suggestive evidence that environmental stimuli, such as dietary pattern, particularly during pregnancy and early life, but also in adult life, can induce changes in DNA methylation predisposing to obesity and related comorbidities. In this context, the DNA methylation marks of each individual have...
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Published on May 2, 2019
Rita Rahmeh1
Estimated H-index: 1
,
Husam Alomirah15
Estimated H-index: 15
+ 1 AuthorsJiwan S. Sidhu4
Estimated H-index: 4
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Published on May 1, 2019in Journal of Colloid and Interface Science 5.09
Xiangsheng Han2
Estimated H-index: 2
(CAS: Chinese Academy of Sciences),
Xiaochen Wu7
Estimated H-index: 7
(CAS: Chinese Academy of Sciences)
+ 1 AuthorsChaoxu Li20
Estimated H-index: 20
(CAS: Chinese Academy of Sciences)
Abstract Proteins are naturally exposed to diverse interfaces in living organisms, from static solid to dynamic fluid. Solid interfaces can enrich proteins as corona, and then catalyze, retard or hinder amyloid fibrillation. But fluid interfaces abundant in biology have rarely been studied for their correlation with protein fibrillation. Unsaturated fatty acids own growing essential roles in diet, whose fluid interfaces are found in vitro to catalyze amyloid fibrillation under certain physiologi...
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Published on May 1, 2019in Science of The Total Environment 4.61
Hamada AbdElgawad17
Estimated H-index: 17
(Beni-Suef University),
Ahmed M. Saleh6
Estimated H-index: 6
(Taibah University)
+ 6 AuthorsWael N. Hozzein12
Estimated H-index: 12
(KSU: King Saud University)
Abstract Actinobacteria have received much attention due to their capacity for plant growth promotion, a promising approach in sustainable development of agriculture. Date palm ( Phoenix dactylifera L.) is an important crop, particularly in semi-arid regions of the world, due to the high nutritional and health-promoting values of its fruits. The present study was conducted to investigate the utilization of actinobacteria as an approach to support soil fertility and enhance production and functio...
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Published on Mar 19, 2019
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Published on Mar 1, 2019in Journal of the American College of Cardiology 16.83
Umut I. Onat2
Estimated H-index: 2
(Bilkent University),
Asli D. Yıldırım2
Estimated H-index: 2
+ 11 AuthorsJon Sin7
Estimated H-index: 7
(Cedars-Sinai Medical Center)
Abstract Background Eukaryotic cells can respond to diverse stimuli by converging at serine-51 phosphorylation on eukaryotic initiation factor 2 alpha (eIF2α) and activate the integrated stress response (ISR). This is a key step in translational control and must be tightly regulated; however, persistent eIF2α phosphorylation is observed in mouse and human atheroma. Objectives Potent ISR inhibitors that modulate neurodegenerative disorders have been identified. Here, the authors evaluated the pot...
2 Citations Source Cite