Interplay between cell cycle and autophagy induced by boswellic acid analog

Anup Singh Pathania; Santosh Kumar Guru; Suresh Kumar; Ashok Kumar; Masroor Ahmad; Shashi Bhushan; Parduman R. Sharma; Priya Mahajan; Bhahwal Ali Shah; Simmi Sharma; Hasan Korkaya; Fayaz Malik

doi:https://doi.org/10.1038/srep33146

doi.org/10.1038/srep33146

Interplay between cell cycle and autophagy induced by boswellic acid analog

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..., Fayaz Malik

26

Scientific Reports4.60

Volume: 6, Issue: 1

Published: Sep 29, 2016

Abstract

In this study, we investigated the role of autophagy induced by boswellic acid analog BA145 on cell cycle progression in pancreatic cancer cells. BA145 induced robust autophagy in pancreatic cancer cell line PANC-1 and exhibited cell proliferation inhibition by inducing cells to undergo G2/M arrest. Inhibition of G2/M progression was associated with decreased expression of cyclin A, cyclin B, cyclin E, cdc2, cdc25c and CDK-1. Pre-treatment of...

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Paper Details

Title

Interplay between cell cycle and autophagy induced by boswellic acid analog

DOI

doi.org/10.1038/srep33146

Published Date

Sep 29, 2016

Journal

Scientific Reports

Volume

6

Issue

1

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