A Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug Effects

Volume: 12, Issue: 9, Pages: e1005111 - e1005111
Published: Sep 27, 2016
Abstract
The molecular mechanisms that translate drug treatment into beneficial and unwanted effects are largely unknown. We present here a novel approach to detect gene-drug and gene-side effect associations based on the phenotypic similarity of drugs and single gene perturbations in mice that account for the polypharmacological property of drugs. We scored the phenotypic similarity of human side effect profiles of 1,667 small molecules and biologicals...
Paper Details
Title
A Novel Drug-Mouse Phenotypic Similarity Method Detects Molecular Determinants of Drug Effects
Published Date
Sep 27, 2016
Volume
12
Issue
9
Pages
e1005111 - e1005111
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