Dietary flavonoid intake and incident coronary heart disease: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study

Published on Nov 1, 2016in The American Journal of Clinical Nutrition6.57
· DOI :10.3945/ajcn.115.129452
Margarethe Goetz4
Estimated H-index: 4
(Emory University),
Suzanne E. Judd6
Estimated H-index: 6
(Emory University)
+ 3 AuthorsViola Vaccarino80
Estimated H-index: 80
(Emory University)
  • References (32)
  • Citations (15)
Published on Mar 1, 2016in European Journal of Nutrition4.45
Kijoon Kim5
Estimated H-index: 5
(SNU: Seoul National University),
Terrence M. Vance9
Estimated H-index: 9
(UConn: University of Connecticut),
Ock K. Chun30
Estimated H-index: 30
(UConn: University of Connecticut)
Purpose This study was conducted to: (1) demonstrate an updated method for estimating flavonoid intake of US adults by combining USDA flavonoid databases and NHANES food consumption data; (2) document the intake and major food sources of flavonoids among US adults; and (3) determine whether the intake and major sources of dietary flavonoids have changed during the past decade in the USA.
Published on Jan 28, 2016in BMJ27.60
Monica L. Bertoia14
Estimated H-index: 14
(Harvard University),
Eric B. Rimm166
Estimated H-index: 166
(Harvard University)
+ 3 AuthorsAedin Cassidy57
Estimated H-index: 57
(UEA: University of East Anglia)
Objective To examine whether dietary intake of specific flavonoid subclasses (including flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, and flavonoid polymers) is associated with weight change over time. Design Three prospective cohort studies. Setting Health professionals in the United States. Participants 124 086 men and women participating in the Health Professionals Follow-up Study (HPFS), Nurses’ Health Study (NHS), and Nurses’ Health Study II (NHS II). Main outcome measure Sel...
Published on Nov 1, 2015in British Journal of Nutrition3.32
Paul F. Jacques98
Estimated H-index: 98
(Tufts University),
Aedin Cassidy57
Estimated H-index: 57
(UEA: University of East Anglia)
+ 2 AuthorsJohanna T. Dwyer76
Estimated H-index: 76
(Tufts University)
This study examines the relationship between long-term intake of six flavonoid classes and incidence of CVD and CHD, using a comprehensive flavonoid database and repeated measures of intake, while accounting for possible confounding by components of a healthy dietary pattern. Flavonoid intakes were assessed using a FFQ among the Framingham Offspring Cohort at baseline and three times during follow-up. Cox proportional hazards regression was used to characterise prospective associations between t...
Published on Sep 1, 2015in Circulation23.05
James M. Shikany46
Estimated H-index: 46
(UAB: University of Alabama at Birmingham),
Monika M. Safford52
Estimated H-index: 52
(UAB: University of Alabama at Birmingham)
+ 3 AuthorsSuzanne E. Judd41
Estimated H-index: 41
(UAB: University of Alabama at Birmingham)
Background—The association of overall diet, as characterized by dietary patterns, with risk of incident acute coronary heart disease (CHD) has not been studied extensively in samples including sociodemographic and regional diversity. Methods and Results—We used data from 17 418 participants in Reasons for Geographic and Racial Differences in Stroke (REGARDS), a national, population-based, longitudinal study of white and black adults aged ≥45 years, enrolled from 2003 to 2007. We derived dietary ...
Published on Jun 1, 2015in Molecular Nutrition & Food Research4.65
H. Amin1
Estimated H-index: 1
(UEA: University of East Anglia),
Charles Czank5
Estimated H-index: 5
(UEA: University of East Anglia)
+ 4 AuthorsColin D. Kay30
Estimated H-index: 30
(UEA: University of East Anglia)
This study was supported by funding from the UK Biotechnology and Biological Sciences Research Council (BBSRC) and the BBSRC Diet and Health Research Industry Club (BBSRC-DRINC), including BB/H532059/1, BB/H004963/1, BB/I006028/1, BB/I005943/1 and BB/J004545/1. A.C. is a Royal Society Wolfson Research Merit Award Holder.
Published on Jan 1, 2015in Food & Function3.24
M. Josepa Salvadó19
Estimated H-index: 19
Ester Casanova10
Estimated H-index: 10
+ 2 AuthorsCinta Bladé31
Estimated H-index: 31
Obesity is a multifactorial disorder involving an abnormal or excessive amount of body fat. Obese people have a very high probability of developing metabolic syndrome, a condition in which cholesterol, lipid, and glucose levels rise, causing diabetes and heart disease. From the point of view of energy balance, the main contributors to obesity are excessive energy intake, inadequate energy expenditure and metabolic malfunctions. For this reason, health organisations are working to implement polic...
Published on Dec 1, 2013in The American Journal of Clinical Nutrition6.57
Shilpa N Bhupathiraju22
Estimated H-index: 22
Nicole M. Wedick19
Estimated H-index: 19
+ 5 AuthorsFrank B. Hu202
Estimated H-index: 202
Background: Dietary guidelines recommend increasing fruit and vegetable intake and, most recently, have also suggested increasing variety. Objective: We prospectively examined the independent roles of quantity and variety in fruit and vegetable intake in relation to incident coronary heart disease (CHD). Design: We prospectively followed 71,141 women from the Nurses’ Health Study (1984–2008) and 42,135 men from the Health Professionals Follow-Up Study (1986–2008) who were free of diabetes, cardi...
Published on Sep 1, 2013in Journal of Nutrition4.42
Paul F. Jacques98
Estimated H-index: 98
(Tufts University),
Aedin Cassidy57
Estimated H-index: 57
(UEA: University of East Anglia)
+ 3 AuthorsJohanna T. Dwyer76
Estimated H-index: 76
(Tufts University)
Substantial experimental evidence suggests that several flavonoid classes are involved in glucose metabolism, but few clinical or epidemiologic studies exist that provide supporting human evidence for this relationship. The objective of this study was to determine if habitual intakes of specific flavonoid classes are related to incidence of type 2 diabetes (T2D). We followed 2915 members of the Framingham Offspring cohort who were free of T2D at baseline from 1991 to 2008. Diabetes was defined b...
Published on Apr 4, 2013in The New England Journal of Medicine70.67
Ramón Estruch73
Estimated H-index: 73
Emilio Ros72
Estimated H-index: 72
+ 15 AuthorsJosé Lapetra36
Estimated H-index: 36
cording to self-reported intake and biomarker analyses. A primary end-point event occurred in 288 participants. The multivariable-adjusted hazard ratios were 0.70 (95% confidence interval (CI), 0.54 to 0.92) and 0.72 (95% CI, 0.54 to 0.96) for the group assigned to a Mediterranean diet with extra-virgin olive oil (96 events) and the group assigned to a Mediterranean diet with nuts (83 events), respectively, ver -
Published on Jan 15, 2013in Circulation23.05
Aedin Cassidy57
Estimated H-index: 57
Kenneth J. Mukamal60
Estimated H-index: 60
+ 3 AuthorsEric B. Rimm166
Estimated H-index: 166
Methods and Results—We followed up 93 600 w omen 25 to 42 years of age from the Nurses’ Health Study (NHS) II who were healthy at baseline (1989) to examine the relationship between anthocyanins and other flavonoids and the risk of MI. Intake of flavonoid subclasses was calculated from validated food-frequency questionnaires collected every 4 years using an updated and extended US Department of Agriculture database. During 18 years of follow-up, 405 cases of MI were reported. An inverse associat...
Cited By15
Published on Aug 26, 2019in The American Journal of Clinical Nutrition6.57
Gowri Raman27
Estimated H-index: 27
(Tufts Medical Center),
Esther E Avendano5
Estimated H-index: 5
(Tufts Medical Center)
+ 5 AuthorsAedin Cassidy ('QUB': Queen's University Belfast)
Published on Jul 22, 2019in Advances in Nutrition7.24
Wilhelmina Kalt21
Estimated H-index: 21
(AAFC: Agriculture and Agri-Food Canada),
Aedin Cassidy57
Estimated H-index: 57
(UEA: University of East Anglia)
+ 4 AuthorsRaul Zamora-Ros34
Estimated H-index: 34
Published on May 1, 2019in Journal of Food Composition and Analysis2.99
Sara L. Anacleto (USP: University of São Paulo), Franco Maria Lajolo43
Estimated H-index: 43
(USP: University of São Paulo),
Neuza Mariko Aymoto Hassimotto12
Estimated H-index: 12
(USP: University of São Paulo)
Abstract A lack of data regarding flavonoid food composition and flavonoid intake has limited the ability to evaluate proposed health benefits effects in populations. We estimated the dietary flavonoids intake of the Brazilian population based on the diet composition obtained through two dietary surveys, which were available from a Food Service and Brazilian Household Budget Survey, using the USDA and Phenol-Explorer databases. The mean daily estimated flavonoid intake was similar when calculate...
Published on Mar 1, 2019in Heliyon
Xianli Wu2
Estimated H-index: 2
(ARS: Agricultural Research Service),
Yang Zhao (ARS: Agricultural Research Service)+ 2 AuthorsPamela R. Pehrsson11
Estimated H-index: 11
(ARS: Agricultural Research Service)
Abstract The flavonoid contents in vegetables are strongly influenced by domestic cooking. The objective of this study was to evaluate the effects of domestic cooking on the structurally complex flavonoids in broccoli. Raw broccoli was cooked by boiling, steaming and microwaving. Seven kaempferol (Km) glycosides and one quercetin (Qn) glycoside were identified and quantified in raw and cooked broccoli by HPLC-MS. Boiling resulted in significant loss of all flavonoids, while steaming and microwav...
Published on Jan 11, 2019
Christine Morand47
Estimated H-index: 47
(INRA: Institut national de la recherche agronomique),
Nicolas Barber-Chamoux5
Estimated H-index: 5
(French Institute of Health and Medical Research)
+ 1 AuthorsDragan Milenkovic19
Estimated H-index: 19
(INRA: Institut national de la recherche agronomique)
Published on Jan 3, 2019in Nutrients4.17
Thu Ha Pham1
Estimated H-index: 1
Sylvain Lecomte7
Estimated H-index: 7
+ 2 AuthorsFarzad Pakdel (EHESP)
Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phytochemicals may have a great potential to prevent and treat chronic diseases. Glyceollins, a group of phytoalexins that are isolated from soybeans, have attracted attention because they exert numerous ...
Published on Nov 13, 2018in Nutrients4.17
Marie Fanelli Kuczmarski17
Estimated H-index: 17
Rhonda Sebastian7
Estimated H-index: 7
+ 6 AuthorsMichele K. Evans37
Estimated H-index: 37
Flavonoids are polyphenolic phytochemicals with health-promoting properties, yet knowledge about their intake in at-risk populations is limited. This study sought to estimate intakes of total flavonoids and six flavonoid classes in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study; determine if differences in intakes exist by race (African American (AA) and White (W)) and income ( 125% Federal poverty guidelines); and compare intakes to those of a nationally rep...
Published on Oct 2, 2018in Critical Reviews in Food Science and Nutrition6.70
Rachel Kimble (Northumbria University), Karen M. Keane7
Estimated H-index: 7
(Northumbria University)
+ 1 AuthorsGlyn Howatson30
Estimated H-index: 30
(Northumbria University)
AbstractAccumulating evidence suggests flavonoid intake is associated with reduced risk of non-communicable diseases. We aimed to systematically determine and quantify the potential association between dietary anthocyanin intake and risk of cardiovascular diseases (CVD). A systematic literature search of studies reporting anthocyanin intake and risk of fatal or nonfatal CVD was performed using SCOPUS, MEDLINE, CINAHL and Cochrane Library. The relative risk (RR) or hazard ratio (HR) of highest ca...
Published on May 1, 2018in Archives of Biochemistry and Biophysics3.56
Allison S. Bardagjy1
Estimated H-index: 1
(UC Davis: University of California, Davis),
Qian Hu (UC Davis: University of California, Davis)+ 2 AuthorsFrancene M. Steinberg20
Estimated H-index: 20
(UC Davis: University of California, Davis)
Abstract This study investigated effects of grape consumption on biomarkers of cardiovascular health in obese participants in both postprandial and chronic settings. Twenty obese adults participated in this randomized, placebo controlled, double-blinded crossover trial. Participants were randomized to consume 60 g freeze-dried polyphenol-rich whole grape powder (GP) or placebo (PBO) followed by high fat high carbohydrate (HFHC) meal challenge. Following acute challenge, participants consumed the...
View next paperAbstract MP19: Specific Dietary Patterns are Associated with Risk of Acute Coronary Heart Disease in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study