Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance

Marie-Claude N. Laffitte; Philippe Leprohon; Barbara Papadopoulou; Marc Ouellette

doi:https://doi.org/10.12688/f1000research.9218.1

doi.org/10.12688/f1000research.9218.1

Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance

Marie-Claude N. Laffitte

6

,

Philippe Leprohon

22

,

..., Marc Ouellette

55

F1000Research

Volume: 5, Pages: 2350 - 2350

Published: Sep 20, 2016

Abstract

Leishmaniahas a plastic genome, and drug pressure can select for gene copy number variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to specific genomic regions. For the latter, the amplification of chromosomal regions occurs at the level of homologous direct or inverted repeated sequences leading to extrachromosomal circular or linear amplified DNAs. This ability...

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Paper Details

Title

Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance

DOI

doi.org/10.12688/f1000research.9218.1

Published Date

Sep 20, 2016

Journal

F1000Research

Volume

5

Pages

2350 - 2350

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