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Sex differences in the risk factors for Staphylococcus aureus throat carriage

Published on Jan 1, 2017in American Journal of Infection Control 1.93
· DOI :10.1016/j.ajic.2016.07.013
Judyta Nowak4
Estimated H-index: 4
(UWr: University of Wrocław),
Barbara Borkowska5
Estimated H-index: 5
(UWr: University of Wrocław),
Bogusław Pawłowski21
Estimated H-index: 21
(UWr: University of Wrocław)
Abstract
Background Male gender and adiposity are considered to be risk factors for Staphylococcus aureus carriage. We tested whether colonization is related to free testosterone (fT) level and adiposity, measured with body mass index (BMI) and body fat percentage (BFP), in healthy adults. Methods Blood sample and throat swabs were taken twice (at 4-week intervals) from healthy men and women aged 18-36 years. fT level, height, weight, and BFP were measured. Participants were classified as persistent carriers, intermittent carriers (excluded from the analyses), and noncarriers. The final sample was 152 participants: 85 men and 67 women. Results BFP, but not BMI, correlated positively with S aureus colonization ( P  = .02) in men. BMI became a significant predictor of carriage only when comparing groups within and above norms ( P  = .04). There was no relationship for BMI nor BFP in women. Higher fT level was related to persistent carriage ( P  = .02) in women, there was no relationship for fT level in men. Conclusion Risk factors for S aureus carriage are sex dependent. Within-sex variation in colonization is related to fT level in women, whereas in men it is related to the amount of body fat.
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References40
Newest
Published on Sep 15, 2015in American Journal of Epidemiology 4.32
Montina Befus7
Estimated H-index: 7
,
Franklin D. Lowy42
Estimated H-index: 42
+ 3 AuthorsElaine Larson69
Estimated H-index: 69
Obesity increases a person's susceptibility to a variety of infections, including Staphylococcus aureus infections, which is an important cause of morbidity in correctional settings. Using a cross-sectional design, we assessed the association between obesity and S. aureus colonization, a risk factor for subsequent infection, in New York State maximum-security prisons (2011-2013). Anterior nares and oropharyngeal cultures were collected. Structured interviews and medical records were used to coll...
11 Citations Source Cite
Published on Apr 1, 2015in Cellular Immunology 3.00
Abhishek Trigunaite4
Estimated H-index: 4
(Cleveland Clinic),
Joana Dimo2
Estimated H-index: 2
(Cleveland Clinic),
Trine N. Jørgensen8
Estimated H-index: 8
(Cleveland Clinic)
Sex-based disparities in immune responses are well known phenomena. The two most important factors accounting for the sex-bias in immunity are genetics and sex hormones. Effects of female sex hormones, estrogen and progesterone are well established, however the role of testosterone is not completely understood. Evidence from unrelated studies points to an immunosuppressive role of testosterone on different components of the immune system, but the underlying molecular mechanisms remains unknown. ...
100 Citations Source Cite
Published on Mar 1, 2015in Obesity 4.04
Ryan W. Grant8
Estimated H-index: 8
(Purdue University),
Vishwa Deep Dixit27
Estimated H-index: 27
(Yale University)
Objective This review will focus on the immunological aspects of adipose tissue and its potential role in development of chronic inflammation that instigates obesity-associated co-morbidities.
125 Citations Source Cite
Published on Oct 1, 2014in American Journal of Infection Control 1.93
E. Botelho-Nevers8
Estimated H-index: 8
(University of Lyon),
Philippe Berthelot24
Estimated H-index: 24
(University of Lyon)
+ 5 AuthorsF. Lucht22
Estimated H-index: 22
(University of Lyon)
The risk factors for Staphylococcus aureus nasal carriage have been mainly defined in healthy volunteers. Using data from a large multicenter prospective clinical cohort of orthopedic surgical patients we showed that obesity (BMI >30) and younger age were independent risk factors for persistent carriage. In the absence of recommendations for S aureus decolonization in orthopedic surgery, this study suggests that at least obese patients should be targeted to prevent surgical site infections.
5 Citations Source Cite
Haydn T. Kissick4
Estimated H-index: 4
(BIDMC: Beth Israel Deaconess Medical Center),
Martin G. Sanda55
Estimated H-index: 55
(Emory University)
+ 4 AuthorsMohamed S. Arredouani14
Estimated H-index: 14
(BIDMC: Beth Israel Deaconess Medical Center)
The hormonal milieu influences immune tolerance and the immune response against viruses and cancer, but the direct effect of androgens on cellular immunity remains largely uncharacterized. We therefore sought to evaluate the effect of androgens on murine and human T cells in vivo and in vitro. We found that murine androgen deprivation in vivo elicited RNA expression patterns conducive to IFN signaling and T-cell differentiation. Interrogation of mechanism showed that testosterone regulates T-hel...
86 Citations Source Cite
Published on May 1, 2014in American Journal of Human Biology 1.57
Bogusław Pawłowski21
Estimated H-index: 21
(UWr: University of Wrocław),
Judyta Nowak4
Estimated H-index: 4
(UWr: University of Wrocław)
+ 1 AuthorsZuzanna Drulis-Kawa18
Estimated H-index: 18
(UWr: University of Wrocław)
Objective Body height, body mass index (BMI) and waist-to-hip ratio (WHR) are the main traits characterizing human body morphology. Studies show that these traits are related to attractiveness and, therefore, according to an evolutionary point of view, are supposed to be honest signals of biological quality. If the immunocompetence handicap principal (IHP) is true, people with more attractive values of these traits should be more immunologically competent. To test this, we analyzed whether nasal...
5 Citations Source Cite
Published on Jan 1, 2014in Infection, Genetics and Evolution 2.54
Johanna U. Ericson Sollid20
Estimated H-index: 20
(University of Tromsø),
Anne-Sofie Furberg21
Estimated H-index: 21
(University of Tromsø)
+ 1 AuthorsMona Johannessen19
Estimated H-index: 19
(University of Tromsø)
Abstract Staphylococcus aureus is a common human commensal but carriage varies between e.g. geographic location, age, gender, ethnicity and body niche. The nares, throat and perineum are the most prevalent sites for carriage in the general adult population. Other sites of the skin and the intestine are also frequently colonised. Thus, a successful establishment is dependent on multiple factors. This review describes results from observational studies of S. aureus carriage and the influence bacte...
66 Citations Source Cite
Published on Nov 1, 2013in American Journal of Cardiology 3.17
John A. Batsis26
Estimated H-index: 26
(Dartmouth College),
Karine R. Sahakyan7
Estimated H-index: 7
(Mayo Clinic)
+ 3 AuthorsFrancisco Lopez-Jimenez51
Estimated H-index: 51
(Mayo Clinic)
Current body mass index (BMI) strata likely misrepresent the accuracy of true adiposity in older adults. Subjects with normal BMI with elevated body fat may metabolically have higher cardiovascular and overall mortality than previously suspected. We identified 4,489 subjects aged ≥60 years (BMI = 18.5 to 25 kg/m 2 ) with anthropometric and bioelectrical impedance measurements from the National Health and Nutrition Examination Surveys III (1988 to 1994) and mortality data linked to the National D...
47 Citations Source Cite
Published on Jun 12, 2013in PLOS ONE 2.77
Courtney A. Cohen2
Estimated H-index: 2
(VT: Virginia Tech),
Amanda A. Shea3
Estimated H-index: 3
(VT: Virginia Tech)
+ 2 AuthorsPaul C. Roberts22
Estimated H-index: 22
(VT: Virginia Tech)
White adipose tissue (WAT) is a multi-faceted endocrine organ involved in energy storage, metabolism, immune function and disease pathogenesis. In contrast to subcutaneous fat, visceral fat (V-WAT) has been associated with numerous diseases and metabolic disorders, indicating specific functions related to anatomical location. Although visceral depots are often used interchangeably in V-WAT-associated disease studies, there has been a recent subdivision of V-WAT into “true visceral” and non-visce...
24 Citations Source Cite
Published on May 7, 2013in PLOS ONE 2.77
Karina Standahl Olsen16
Estimated H-index: 16
(University of Tromsø),
Kjersti Danielsen4
Estimated H-index: 4
(University of Tromsø)
+ 6 AuthorsAnne-Sofie Furberg21
Estimated H-index: 21
(University of Tromsø)
This paper is part of Karina Olsen's doctoral thesis, available in Munin at http://hdl.handle.net/10037/5596
29 Citations Source Cite
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Published on Nov 30, 2018in PLOS ONE 2.77
Jialing Lin3
Estimated H-index: 3
(Guangdong Pharmaceutical University),
Ting Zhang3
Estimated H-index: 3
(Guangdong Pharmaceutical University)
+ 3 AuthorsZhenjiang Yao8
Estimated H-index: 8
(Guangdong Pharmaceutical University)
Objective We aim to assess the similarities of proportional, phenotypic, and molecular characteristics between the school environment and schoolchildren on methicillin-sensitive S. aureus (MSSA) isolates. Methods A cross-sectional study was conducted between March 2016 and August 2016 in eight elementary schools in Guangzhou, China. Nasal swabs from students and environmental swabs from school environments were collected. Univariate and multivariate logistic regression analyses under a multistag...
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