Original paper

Comparative analysis of anti-polyglutamine Fab crystals grown on Earth and in microgravity

Volume: 72, Issue: 10, Pages: 762 - 771
Published: Sep 22, 2016
Abstract
Huntington's disease is one of nine neurodegenerative diseases caused by a polyglutamine (polyQ)-repeat expansion. An anti-polyQ antigen-binding fragment, MW1 Fab, was crystallized both on Earth and on the International Space Station, a microgravity environment where convection is limited. Once the crystals returned to Earth, the number, size and morphology of all crystals were recorded, and X-ray data were collected from representative...
Paper Details
Title
Comparative analysis of anti-polyglutamine Fab crystals grown on Earth and in microgravity
Published Date
Sep 22, 2016
Volume
72
Issue
10
Pages
762 - 771
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