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Interleukin-33 in health and disease

Published on Nov 1, 2016in Nature Reviews Immunology44.02
· DOI :10.1038/nri.2016.95
Foo Y. Liew94
Estimated H-index: 94
,
Jean-Philippe Girard47
Estimated H-index: 47
,
Heth R. Turnquist14
Estimated H-index: 14
Cite
Abstract
The cytokine interleukin-33 was first identified as an inducer of type 2 immune responses. It has now been shown to have pleiotropic activities on multiple immune cell types and is involved in numerous infectious and inflammatory diseases, as described in this Review.
  • References (188)
  • Citations (159)
Cite
References188
Newest
Published on Jul 21, 2016in Blood16.56
Benjamin M. Matta11
Estimated H-index: 11
(University of Pittsburgh),
Dawn K. Reichenbach6
Estimated H-index: 6
(UMN: University of Minnesota)
+ 12 AuthorsColby J. Feser2
Estimated H-index: 2
(UMN: University of Minnesota)
During allogeneic hematopoietic cell transplantation (alloHCT), nonhematopoietic cell interleukin-33 (IL-33) is augmented and released by recipient conditioning to promote type 1 alloimmunity and lethal acute graft-versus-host disease (GVHD). Yet, IL-33 is highly pleiotropic and exhibits potent immunoregulatory properties in the absence of coincident proinflammatory stimuli. We tested whether peri-alloHCT IL-33 delivery can protect against development of GVHD by augmenting IL-33–associated regul...
Amy Kit Yu Fu11
Estimated H-index: 11
(HKUST: Hong Kong University of Science and Technology),
Kwok Wang Hung6
Estimated H-index: 6
(HKUST: Hong Kong University of Science and Technology)
+ 8 AuthorsFoo Y. Liew94
Estimated H-index: 94
(Soochow University (Suzhou))
Alzheimer’s disease (AD) is a devastating condition with no known effective treatment. AD is characterized by memory loss as well as impaired locomotor ability, reasoning, and judgment. Emerging evidence suggests that the innate immune response plays a major role in the pathogenesis of AD. In AD, the accumulation of β-amyloid (Aβ) in the brain perturbs physiological functions of the brain, including synaptic and neuronal dysfunction, microglial activation, and neuronal loss. Serum levels of solu...
Published on May 4, 2016in Science Translational Medicine17.16
Kevin M. Vannella11
Estimated H-index: 11
(NIH: National Institutes of Health),
Thirumalai R. Ramalingam28
Estimated H-index: 28
(NIH: National Institutes of Health)
+ 10 AuthorsAlison L. Budelsky17
Estimated H-index: 17
(Amgen)
Thymic stromal lymphopoietin (TSLP), interleukin-25 (IL-25), and IL-33 are important initiators of type 2–associated mucosal inflammation and immunity. However, their role in the maintenance of progressive type 2 inflammation and fibrosis is much less clear. Using chronic models of helminth infection and allergic lung inflammation, we show that collective disruption of TSLP, IL-25, and IL-33 signaling suppresses chronic and progressive type 2 cytokine–driven inflammation and fibrosis. In a schis...
Published on Mar 1, 2016in American Journal of Transplantation7.16
Lisa Mathews5
Estimated H-index: 5
(University of Pittsburgh),
Jeremy M. Lott4
Estimated H-index: 4
(University of Pittsburgh)
+ 10 AuthorsAdriana Zeevi63
Estimated H-index: 63
(University of Pittsburgh)
Elevated serum soluble (s) suppressor of tumorigenicity-2 is observed during cardiovascular and inflammatory bowel diseases. To ascertain whether modulated ST2 levels signify heart (HTx) or small bowel transplant (SBTx) rejection, we quantified sST2 in serially obtained pediatric HTx (n = 41) and SBTx recipient (n = 18) sera. At times of biopsy-diagnosed HTx rejection (cellular and/or antibody-mediated), serum sST2 was elevated compared to rejection-free time points (1714 ± 329 vs. 546.5 ± 141.6...
Published on Feb 8, 2016in Journal of Experimental Medicine10.89
Hongkang Xi6
Estimated H-index: 6
(Genentech),
Kenneth J. Katschke18
Estimated H-index: 18
(Genentech)
+ 13 AuthorsJeffrey Eastham-Anderson22
Estimated H-index: 22
(Genentech)
Age-related macular degeneration (AMD), a leading cause of vision impairment in the ageing population, is characterized by irreversible loss of retinal pigment epithelial (RPE) cells and photoreceptors and can be associated with choroidal neovascularization. Mononuclear phagocytes are often present in AMD lesions, but the processes that direct myeloid cell recruitment remain unclear. Here, we identify IL-33 as a key regulator of inflammation and photoreceptor degeneration after retina stress or ...
Published on Feb 1, 2016in Journal of Investigative Dermatology6.29
Gregory D. Rak9
Estimated H-index: 9
(UPenn: University of Pennsylvania),
Lisa C. Osborne19
Estimated H-index: 19
(Cornell University)
+ 5 AuthorsSusan W. Volk18
Estimated H-index: 18
(UPenn: University of Pennsylvania)
Breaches in the skin barrier initiate an inflammatory immune response that is critical for successful wound healing. Innate lymphoid cells (ILCs) are a recently identified population of immune cells that reside at epithelial barrier surfaces such as the skin, lung, and gut, and promote proinflammatory or epithelial repair functions after exposure to allergens, pathogens, or chemical irritants. However, the potential role of ILCs in regulating cutaneous wound healing remains undefined. Here, we d...
Published on Feb 1, 2016in Immunity21.52
Wilson Kuswanto4
Estimated H-index: 4
(Harvard University),
Dalia Burzyn5
Estimated H-index: 5
(Harvard University)
+ 5 AuthorsDiane Mathis113
Estimated H-index: 113
(Harvard University)
Summary Normal repair of skeletal muscle requires local expansion of a special population of Foxp3 + CD4 + regulatory T (Treg) cells. Such cells failed to accumulate in acutely injured muscle of old mice, known to undergo ineffectual repair. This defect reflected reduced recruitment of Treg cells to injured muscle, as well as less proliferation and retention therein. Interleukin-33 (IL-33) regulated muscle Treg cell homeostasis in young mice, and its administration to old mice ameliorated their ...
Published on Jan 1, 2016in Experimental Dermatology2.87
James S. Lee3
Estimated H-index: 3
(UQ: University of Queensland),
Elke Seppanen7
Estimated H-index: 7
(UQ: University of Queensland)
+ 2 AuthorsKiarash Khosrotehrani32
Estimated H-index: 32
(UQ: University of Queensland)
Published on Jan 1, 2016in Mucosal Immunology7.35
Alexander Mohapatra4
Estimated H-index: 4
,
S J Van Dyken1
Estimated H-index: 1
+ 3 AuthorsRichard M. Locksley89
Estimated H-index: 89
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis
Published on Nov 1, 2015in Nature Communications11.88
E. Suzanne Cohen5
Estimated H-index: 5
,
Ian C. Scott19
Estimated H-index: 19
+ 28 AuthorsNicholas J. Bond2
Estimated H-index: 2
In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little is known about the regulation of IL-33 following its release. Here we report that the biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by the formation of two disulphide bridges, resulting in an extensive conformational change that disrupts the ST2 binding site. Both reduced (active) ...
Cited By159
Newest
Published on Mar 7, 2019in Scientific Reports4.01
Lia Ginaldi20
Estimated H-index: 20
(University of L'Aquila),
Massimo De Martinis16
Estimated H-index: 16
(University of L'Aquila)
+ 5 AuthorsSebastiano Gangemi26
Estimated H-index: 26
(UNIME: University of Messina)
There are many cytokines involved in the pathogenesis of osteoporosis. So far IL-33 involvement in osteoporotic patients has not yet been studied. IL-33 is a pro-inflammatory cytokine which mediates several immune functions; its involvement in a wide range of diseases, such as atopic dermatitis, asthma, and rheumatoid arthritis, is now emerging. In view of the crucial role of this cytokine in inflammation and bone remodeling, we measured IL-33 levels in the serum of postmenopausal women with ost...
Published on 2019in Scientific Reports4.01
Melanie Buckley6
Estimated H-index: 6
(Cardiff University),
Jessica Williams3
Estimated H-index: 3
(Cardiff University)
+ 4 AuthorsDipak Purshottam Ramji29
Estimated H-index: 29
(Cardiff University)
Atherosclerosis, a chronic inflammatory disorder of the walls of arteries, causes more deaths worldwide than any other disease. Cytokines, which are present at high levels in atherosclerotic plaques, play important roles in regulating the initiation and the progression of the disease. Previous studies using animal and cell culture model systems revealed protective, anti-atherogenic effects of the cytokine interleukin-33 (IL-33). The action of this cytokine involves both the induction and suppres...
Published on Dec 1, 2019in Journal of Surgical Research1.87
Isabel M. Billiar (University of Pittsburgh), Jesse Guardado4
Estimated H-index: 4
(University of Pittsburgh)
+ 3 AuthorsRami A. Namas14
Estimated H-index: 14
(University of Pittsburgh)
Abstract Background Soluble suppression of tumorigenicity 2 (sST2), a decoy receptor for interleukin (IL)-33, has emerged as a novel biomarker in various disease processes. Recent studies have elucidated the role of the sST2/IL-33 complex in modulating the balance of Th1/Th2 immune responses after tissue stress. However, the role of sST2 as a biomarker after traumatic injury remains unclear. To address this, we evaluated serum sST2 correlations with mortality and in-hospital adverse outcomes as ...
Published on Dec 1, 2019in Nature Communications11.88
Moritz F. Eissmann5
Estimated H-index: 5
(La Trobe University),
Christine D. Dijkstra67
Estimated H-index: 67
(La Trobe University)
+ 14 AuthorsNicholas D. Huntington34
Estimated H-index: 34
(WEHI: Walter and Eliza Hall Institute of Medical Research)
The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess the impact of tumor-adjacent, submucosal mast cell accumulation in murine and human intestinal-type gastric cancer. We find that genetic ablation or therapeutic inactivation of mast cells suppresses accumulation of tumor-associated macrophages, reduces tumor cell proliferation and angiogenesis, and diminishes tumor burden. Mast cells are activated by interleukin (IL)-33...
Published on Oct 1, 2019in Journal of Investigative Dermatology6.29
Bernhard Ryffel61
Estimated H-index: 61
(University of Orléans),
José C. Alves-Filho30
Estimated H-index: 30
(USP: University of São Paulo)
In this issue, Imai et al. (2019) provide new insights into the pathophysiology of AD-like inflammation using their model (Imai et al., 2013) and ask how ILC2s and basophils contribute to the IL-33–induced AD-like inflammation. Their findings show that continuous expression of IL-33 in keratinocytes is sufficient to cause AD-like inflammation in mice, and that this occurrence is largely independent of adaptive immune cells and is mediated by basophils and ILC2s.
Published on Oct 1, 2019in Nature Reviews Rheumatology18.55
Charles A. Dinarello173
Estimated H-index: 173
(Radboud University Nijmegen)
More than any other cytokine family, the 11 members of the IL-1 family are associated with innate immune responses, which occur in acute inflammation and chronic inflammatory conditions such as rheumatic diseases. In many rheumatic diseases, the severity of the condition can result from the balance between the pro-inflammatory and anti-inflammatory members of the IL-1 family. Pro-inflammatory family members (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β and IL-36γ) are found in the articular enviro...
Published on Sep 13, 2019in Frontiers in Immunology4.72
Bernhard Ryffel61
Estimated H-index: 61
,
Milena Sokolowska15
Estimated H-index: 15
(Swiss Institute of Allergy and Asthma Research)
+ 3 AuthorsDieudonnée Togbe20
Estimated H-index: 20
Ozone exposure causes irritation, airway hyperreactivity (AHR) and inflammation of the airways in man and mice. This review focuses on the acute disruption of the respiratory barrier in mice. A single high dose ozone exposure (1 ppm for 1h) causes first a break of the respiratory barrier within 2h with leak of serum proteins in the broncho-alveolar space, disruption of epithelial tight junctions and cell death, which is followed at 6h by ROS activation, AHR, myeloid cell recruitment and remodeli...
Published on Sep 10, 2019in Viruses3.81
Chae Won Kim , Hye Jee Yoo + 2 AuthorsHeung Kyu Lee17
Estimated H-index: 17
Influenza is an infectious respiratory illness caused by the influenza virus. Though vaccines against influenza exist, they have limited efficacy. To additionally develop effective treatments, there is a need to study the mechanisms of host defenses from influenza viral infections. To date, the mechanism by which interleukin (IL)-33 modulates the antiviral immune response post-influenza infection is unclear. In this study, we demonstrate that exogenous IL-33 enhanced antiviral protection against...
View next paperIL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo.