ID 515 – Mood dysregulation, sex and sex hormones predict stress response circuitry deficits

Inspired by the NIMH RDoC initiative to determine biosignatures associated with regulation of arousal and negative affect across psychiatric disorders, we used a mild visual stress task to conduct a functional magnetic resonance imaging (fMRI) study investigating the impact of depressed mood on stress circuitry function in major depressive disorder, psychosis and healthy controls (n = 99). fMRI data were analyzed using SPM8 and task-related...