Integration of common feature pharmacophore modeling and in vitro study to identify potent AChE inhibitors
Abstract
Alzheimer’s disease is a progressive neurodegenerative disorder arising due to genetic and non-genetic causes. One of the major therapies adapted for symptomatic Alzheimer’s disease is by targeting acetylcholinesterase enzyme based on the cholinergic hypothesis. Acetylcholinesterase is a substrate-specific enzyme that degrades the neuro-transmitter acetylcholine. An optimum level of acetylcholine should be maintained in the brain for its proper...
Paper Details
Title
Integration of common feature pharmacophore modeling and in vitro study to identify potent AChE inhibitors
Published Date
Sep 13, 2016
Journal
Volume
25
Issue
12
Pages
2965 - 2975
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