Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication
Abstract
The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1-CUL4-ROC1 (CRL4) E3 ligase is critical for this function. Using substrate-trapping proteomics, we identified the structural maintenance of chromosomes (SMC) complex proteins SMC5 and SMC6 as CRL4(HBx) substrates. HBx expression and HBV infection degraded the SMC5/6 complex...
Paper Details
Title
Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication
Published Date
Sep 1, 2016
Journal
Volume
16
Issue
11
Pages
2846 - 2854
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