Human Topoisomerase I mediated cytotoxicity profile of l-valine-quercetin diorganotin(IV) antitumor drug entities

New chiral L-/d-valine-quercetin diorganotin(IV) complexes [(CH3)2Sn(Q)(val)] 1L/D, [(C6H5)2Sn(Q)(val)] 2L/D, were synthesized and thoroughly characterized by elemental analysis, mass spectrometry, IR, 1H NMR, 119Sn NMR spectroscopy. Preliminary comparative DNA binding studies on enantiomeric complexes 1L/D and 2L/D were carried out by UV–vis, fluorescence titrations, thermal denaturation and circular dichroic techniques to ascertain their DNA...