Integrated stress response of vertebrates is regulated by four eIF2α kinases.
Abstract
The integrated stress response (ISR) is a cytoprotective pathway initiated upon phosphorylation of the eukaryotic translation initiation factor 2 (eIF2α) residue designated serine-51, which is critical for translational control in response to various stress conditions. Four eIF2α kinases, namely heme-regulated inhibitor (HRI), protein kinase R (PKR), PKR-like endoplasmic reticulum kinase, (PERK) and general control non-depressible 2 (GCN2), have...
Paper Details
Title
Integrated stress response of vertebrates is regulated by four eIF2α kinases.
Published Date
Sep 16, 2016
Journal
Volume
6
Issue
1
Pages
32886 - 32886
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