NOTCH1 mediates a switch between two distinct secretomes during senescence

Volume: 18, Issue: 9, Pages: 979 - 992
Published: Sep 1, 2016
Abstract
Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence is accompanied by a dynamic fluctuation of NOTCH1 activity, which drives a TGF-β-rich secretome, while suppressing the senescence-associated pro-inflammatory secretome through inhibition of C/EBPβ. NOTCH1 and...
Paper Details
Title
NOTCH1 mediates a switch between two distinct secretomes during senescence
Published Date
Sep 1, 2016
Volume
18
Issue
9
Pages
979 - 992
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