Generation and in vitro characterisation of inhibitory nanobodies towards plasminogen activator inhibitor 1
Abstract
Summary Plasminogen activator inhibitor 1 (PAI-1) is the principal physiological inhibitor of tissue-type plasminogen activator (t-PA) and has been identified as a risk factor in cardiovascular diseases. In order to generate nanobodies against PAI-1 to interfere with its functional properties, we constructed three nanobody libraries upon immunisation of three alpacas with three different PAI-1 variants. Three panels of nanobodies were selected...
Paper Details
Title
Generation and in vitro characterisation of inhibitory nanobodies towards plasminogen activator inhibitor 1
Published Date
Nov 1, 2016
Journal
Volume
116
Issue
12
Pages
1032 - 1040
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