Original paper
USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability
Abstract
Excessive accumulation of DNA damage will generate chromosome stress, leading to various chromosome abnormalities such as chromatin bridge and result in genomic instability. Orchestra procession and regulation of DNA damage repair are vital for keeping genome stability. Despite of the key role of HDAC1/2 in double strand break (DSB) repair, the regulation for their mode of action is less well understood. In this study, we found that...
Paper Details
Title
USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability
Published Date
Aug 8, 2016
Journal
Volume
8
Issue
2
Pages
2197 - 2208
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Notes
History