Extrusion–spheronization a promising pelletization technique: In-depth review

This review article deals with various aspects of the extrusion–spheronization technique. The first part includes different steps in the production process of pellets such as granulation, extrusion, spheronization, and drying. In the second part, the parameters which can influence the quality of pellets including formulation (moisture content, granulating liquid, excipients, and drugs), equipment (mixer, extruder, friction plate, and extrusion...