Original paper
QSAR modeling to design selective histone deacetylase 8 (HDAC8) inhibitors
Abstract
HDAC8 inhibitors have become an attractive treatment for cancer. This study aimed to facilitate the identification of potential chemical scaffolds for the selective inhibition of histone deacetylase 8 (HDAC8) using in silico approaches. Non-linear QSAR classification and regression models of HDAC8 inhibitors were developed with support vector machine. Mean impact value-based sequential forward feature selection and grid search strategy were used...
Paper Details
Title
QSAR modeling to design selective histone deacetylase 8 (HDAC8) inhibitors
Published Date
Aug 19, 2016
Volume
39
Issue
10
Pages
1356 - 1369
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Notes
History