NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations
Abstract
Inflammasomes are positioned to rapidly escalate the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by pyroptosis. However, negative regulation of inflammasomes remains poorly understood, as is the signaling cascade that dampens inflammasome activity. We found that rapid NLRP3 inflammasome activation was directly inhibited by protein kinase A (PKA), which was induced by prostaglandin E2 (PGE2) signaling via the...
Paper Details
Title
NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations
Published Date
Aug 22, 2016
Journal
Volume
17
Issue
10
Pages
1176 - 1186
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History