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Wound Diagnostics and Diagnostic Dressings

Published on Jan 1, 2016
· DOI :10.1016/B978-0-12-803762-1.00005-9
James Davis30
Estimated H-index: 30
(Ulster University),
A. McLister1
Estimated H-index: 1
(Ulster University)
Diagnostics play an increasingly important role in the wound management plan for chronic wounds as they can provide valuable insights into why a wound is failing to progress. Active interventions to encourage healing will often require several different approaches and there is little doubt that the provision of detailed information on the chemical dynamics at play within the wound environment would be of tremendous benefit in facilitating more informed treatment decisions and dressing selection. The latter can be pivotal in encouraging the wound to move between different stages in healing. While there have been substantial developments in diagnostic technologies, it is only recently that their application within a wound-healing context has come to the fore. The realization of smart systems that could be used to promote healing but, which could also provide feedback or telemetry on the healing dynamics, is however now beginning to appear with increasing regularity within the research literature. This chapter provides an overview of the challenges involved in the development of such systems from simple dipstick tests through to the devices intended to be worn by the patient. Questions over sampling, selecting appropriate target biomarkers, and adapting analytical methodologies from laboratory-based detection to a system that can be applied directly within the clinic, the home or integrated within a conventional wound dressing, are discussed in depth. The foundations of the proposed methodologies are explored and the practicalities of their implementation within a wound context are critically assessed.
  • References (84)
  • Citations (1)
Published on May 13, 2005in Sensors and Actuators B-chemical 5.67
Sawada Kazuaki26
Estimated H-index: 26
(Toyohashi University of Technology),
Takahiro Ohshina3
Estimated H-index: 3
(Toyohashi University of Technology)
+ 2 AuthorsMakoto Ishida33
Estimated H-index: 33
(Toyohashi University of Technology)
A novel sensor device, comprising of fused photo-sensors and ion-sensors, is proposed. We describe how a prototype device was successfully fabricated using a CMOS process. In the proposed device, a photo-sensor and an ion-sensor are fused in the same pixel, enabling the photo-signal and the ion concentration density to be detected simultaneously in the same sensing area. Therefore, the relationship between light distribution and ion distribution can be clarified by using this novel sensor array....
89 Citations Source Cite
Published on Jun 25, 2015in Healthcare
Anna McLister4
Estimated H-index: 4
(Ulster University),
James Davis30
Estimated H-index: 30
It has been proposed that fluctuations in wound pH can give valuable insights into the healing processes in chronic wounds, but acquiring such data can be a technological challenge especially where there is little sample available. Developments in voltammetric pH sensing have opened up new avenues for the design of probes that can function in ultra-small volumes and can be inherently disposable but, as yet few can meet the demands of wound monitoring. A preliminary investigation of the pH respon...
5 Citations Source Cite
Published on Jan 1, 2010
Fritz Scholz1
Estimated H-index: 1
I Basic Electrochemistry.- The Electrical Double Layer and Its Structure.- Thermodynamics of Electrochemical Reactions.- Kinetics of Electrochemical Reactions.- Electroanalytical Techniques.- Cyclic Voltammetry.- Pulse Voltammetry.- Square-Wave Voltammetry.- Chronocoulometry.- Electrochemical Impedance Spectroscopy.- UV/Vis/NIR Spectroelectrochemistry.- Stripping Voltammetry.- Electrochemical Studies of Solid Compounds and Materials.- Potentiometry.- Electrochemical Quartz Crystal Nanobalance.- ...
243 Citations
Published on Jan 1, 2002in Analytica Chimica Acta 5.12
Xueji Zhang32
Estimated H-index: 32
Božidar Ogorevc24
Estimated H-index: 24
Joseph Wang123
Estimated H-index: 123
(New Mexico State University)
Abstract An ultramicro pH sensor has been constructed based on a thin polyaniline film that was electrochemically deposited onto a carbon fiber nanometer-size electrode. The substrate nanoelectrodes were fabricated using ion-beam conically etched carbon fibers with tip diameters ranging ca. from 100 to 500 nm. The polyaniline film was deposited from HCl solution containing the aniline monomer by cycling the potential between −0.2 and +1.0 V. The electromotive force (emf) signal between the pH se...
87 Citations Source Cite
Published on Jan 1, 2011in Physical Chemistry Chemical Physics 3.91
Stéphane Fierro15
Estimated H-index: 15
(École Polytechnique Fédérale de Lausanne),
Naoko Mitani3
Estimated H-index: 3
(Keio University)
+ 1 AuthorsYasuaki Einaga45
Estimated H-index: 45
(Keio University)
The boron doped diamond (BDD) electrode is presented as an appropriate candidate for next generation glass-free, highly stable and accurate pH sensors. The method used in this study is based on the potential change related to the hydrogen evolution reaction following a current step, which is pH dependent. Alkali cations in the solution have no influence on the accuracy of the pH calibration curve, which provides an advantage with respect to the conventional pH glass electrode. The unwanted influ...
16 Citations Source Cite
Markus Loeffler77
Estimated H-index: 77
(University of Tübingen),
Heiko Schuster13
Estimated H-index: 13
(University of Tübingen)
+ 1 AuthorsStefan Beckert17
Estimated H-index: 17
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Published on Nov 1, 2009in Diabetes Care 13.40
Yu Liu3
Estimated H-index: 3
Danqing Min9
Estimated H-index: 9
+ 4 AuthorsSusan V. McLennan30
Estimated H-index: 30
We thank the authors for their comment (1) on our study (2) and we agree that the pathophysiology of diabetic foot ulcers is complex and not well understood. We recognize that we are not the first to establish a potential role for matrix metalloproteinase-9 (MMP-9) in chronic wound healing. However, we report that its measurement …
15 Citations Source Cite
Published on Dec 1, 2003in Journal of Electroanalytical Chemistry 3.23
Tom Lindfors27
Estimated H-index: 27
(Åbo Akademi University),
Sini Ervelä1
Estimated H-index: 1
(Åbo Akademi University),
Ari Ivaska47
Estimated H-index: 47
(Åbo Akademi University)
Abstract The pH and redox sensitivity of electrically conducting polymer films consisting of a mixture of polyaniline (PANI) and plasticized poly(vinyl chloride) (PVC) have been studied with potentiometry, UV–vis spectroscopy and energy dispersive X-ray analysis (EDXA). It is well known that PANI is highly H + -selective and can easily be dissolved in many organic solvents with functionalized organic acids. PANI is therefore very suitable to be used as a H + -sensitive component in plasticized P...
45 Citations Source Cite
Published on Feb 1, 2010in Proteomics Clinical Applications 3.57
James A. Broadbent7
Estimated H-index: 7
(Queensland University of Technology),
Terence Patrick Walsh17
Estimated H-index: 17
(Queensland University of Technology),
Zee Upton31
Estimated H-index: 31
(Queensland University of Technology)
Chronic wounds, such as venous and diabetic leg ulcers, represent a significant health and financial burden to individuals and healthcare systems. In worst-case scenarios this condition may require the amputation of an affected limb, with significant impact on patient quality of life and health. Presently, there are no clinical biochemical analyses used in the diagnosis and management of this condition; moreover few biochemical therapies are accessible to patients. This presents a significant ch...
21 Citations Source Cite
Published on Jan 1, 2015in Sensors and Actuators B-chemical 5.67
Gerhard J. Mohr5
Estimated H-index: 5
(Joanneum Research),
Heidrun Müller2
Estimated H-index: 2
(University of Jena)
Abstract The appropriate combination of absorbance-based indicator dyes and inert dyes allows colour changes from green to red to be observed. In detail, a pH indicator with a yellow to red colour change upon exposure to alkaline buffers is combined with a blue and pH-insensitive dye. The resulting colour change of indicator plus inert dye is more easily visible than the original colour change and is more easily interpreted in terms of a “traffic light” change. The approach can be used in optica...
13 Citations Source Cite
Cited By1
Published on Jun 2, 2018in Journal of Wound Care 1.67
Mouna Messaoud , Cyril Marsiquet (French Alternative Energies and Atomic Energy Commission)+ 2 AuthorsGilles Marchand9
Estimated H-index: 9
(French Alternative Energies and Atomic Energy Commission)
Objective: Few studies have investigated methods to monitor the moisture distribution and filling percentage of dressings during wound management. In this study, a new system allowing moisture monitoring across the wound dressing to be measured is examined. Method: The system is composed of a wound bed model with a fluid injection system to mimic exudate flow, a flexible sensor array and data acquisition software. The sensor is composed of 14 flexible electrode arrays, screen-printed on a flexib...
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