Calcinosis is associated with digital ischaemia in systemic sclerosis—a longitudinal study

To determine if ischaemia is a causal factor in the development of calcinosis in SSc.Patients with SSc were assessed yearly. Physicians reported the presence of calcinosis, digital ischaemia (digital ulcers, digital necrosis/gangrene, loss of digital pulp on any digits and/or auto- or surgical digital amputation) and nailfold capillary dropout assessed using a dermatoscope. The number of digits with digital ischaemia was used as an assessment of...